Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Via Accademia Albertina 13, Turin 10123, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, Orbassano 10043, Italy.
Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Via Accademia Albertina 13, Turin 10123, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, Orbassano 10043, Italy; Institute de Biologie Valrose (iBV), Université Cote d'Azur (UCA), CNRS 7277, Inserm 1091, Avenue Valrose 28, Nice 06108, France.
Neurobiol Dis. 2024 Sep;199:106604. doi: 10.1016/j.nbd.2024.106604. Epub 2024 Jul 11.
Mitochondria are essential regulators of cellular energy metabolism and play a crucial role in the maintenance and function of neuronal cells. Studies in the last decade have highlighted the importance of mitochondrial dynamics and bioenergetics in adult neurogenesis, a process that significantly influences cognitive function and brain plasticity. In this review, we examine the mechanisms by which mitochondria regulate adult neurogenesis, focusing on the impact of mitochondrial function on the behavior of neural stem/progenitor cells and the maturation and plasticity of newborn neurons in the adult mouse hippocampus. In addition, we explore the link between mitochondrial dysfunction, adult hippocampal neurogenesis and genes associated with cognitive deficits in neurodevelopmental disorders. In particular, we provide insights into how alterations in the transcriptional regulator NR2F1 affect mitochondrial dynamics and may contribute to the pathophysiology of the emerging neurodevelopmental disorder Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS). Understanding how genes involved in embryonic and adult neurogenesis affect mitochondrial function in neurological diseases might open new directions for therapeutic interventions aimed at boosting mitochondrial function during postnatal life.
线粒体是细胞能量代谢的重要调节者，在神经元细胞的维持和功能中起着关键作用。过去十年的研究强调了线粒体动力学和生物能量学在成人神经发生中的重要性，这一过程对认知功能和大脑可塑性有重大影响。在这篇综述中，我们探讨了线粒体调节成人神经发生的机制，重点关注线粒体功能对神经干细胞/祖细胞行为以及成年小鼠海马中新神经元成熟和可塑性的影响。此外，我们还探讨了线粒体功能障碍、成年海马神经发生与神经发育障碍相关认知缺陷基因之间的联系。特别是，我们深入了解转录调节因子 NR2F1 的改变如何影响线粒体动力学，并可能导致新兴神经发育障碍 Bosch-Boonstra-Schaaf 视神经萎缩综合征 (BBSOAS) 的病理生理学。了解参与胚胎和成年神经发生的基因如何影响神经疾病中线粒体功能，可能为旨在促进出生后生活中线粒体功能的治疗干预开辟新的方向。
