Department of dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
Department of dermatology, The Second Affiliated Hospital of Wannan Medical college,10 Kangfu Road, Wuhu, 241000,China.
Photodiagnosis Photodyn Ther. 2024 Aug;48:104273. doi: 10.1016/j.pdpdt.2024.104273. Epub 2024 Jul 11.
Dermatosis papulosa nigra (DPN) is a type of benign epidermal hyperplasia that affects the appearance of patients and poses a threat to their physical and mental health. Photodynamic therapy (PDT) has been shown to have the advantages of non-invasiveness, efficacy, and low recurrence in the treatment of skin disorders. However, no studies have been reported on the use of PDT for the treatment of DPN. Therefore, we used PDT for the first time to treat DPN and monitor its efficacy. Forty-five patients with DPN diagnosed at the outpatient clinic of Changzhou First People's Hospital were treated with 10 % 5-aminolevulinic acid (ALA) once a week for four consecutive weeks and followed for 3 months. After four treatment sessions, the cure rate among the 45 patients was 71.1 %, and the overall efficacy rate was 93.3 %. The most common adverse reactions were mild erythema, edema, and temporary pigmentation. PDT is expected to become a new and effective treatment for DPN.
色素性丘疹病（DPN）是一种良性表皮增生，影响患者的外观，对其身心健康构成威胁。光动力疗法（PDT）已被证明在治疗皮肤疾病方面具有非侵入性、疗效好和复发率低的优点。然而，目前尚无关于 PDT 治疗 DPN 的研究报告。因此，我们首次使用 PDT 治疗 DPN 并监测其疗效。我们对在常州市第一人民医院门诊诊断为 DPN 的 45 例患者进行了治疗，每周使用 10%的 5-氨基酮戊酸（ALA）一次，连续四周，并随访 3 个月。经过四次治疗后，45 例患者的治愈率为 71.1%，总有效率为 93.3%。最常见的不良反应是轻度红斑、水肿和暂时的色素沉着。PDT 有望成为 DPN 的一种新的有效治疗方法。
