Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.
Clin Exp Dermatol. 2012 Apr;37(3):235-7. doi: 10.1111/j.1365-2230.2011.04189.x. Epub 2012 Feb 2.
Lymphocytic infiltration of the skin (LIS) is a relatively uncommon skin condition, first described by Jessner and Kanof in 1953. LIS presents mainly on the face, in particular on the cheeks and earlobe, but also on the neck, upper trunk or proximal limbs of middle-aged adults. LIS is often resistant to treatment. Photodynamic therapy (PDT) refers to the process of applying a topical prodrug, such as 5-aminolaevulinic acid (ALA) or methyl 5-aminolaevulinic acid (MAL), followed by irradiation with visible or ultraviolet light. The prodrug is converted by target tissue to photoactive porphyrins, which lead to local tissue destruction when activated by light. We describe a 48-year-old woman with refractory LIS, who was treated with MAL-PDT.
皮肤淋巴细胞浸润症（LIS）是一种相对少见的皮肤疾病，于 1953 年由 Jessner 和 Kanof 首次描述。LIS 主要发生在面部，特别是脸颊和耳垂，但也可发生在颈部、上躯干或中年人的近端肢体上。LIS 通常对抗生素治疗有抗性。光动力疗法（PDT）是指应用局部前体药物（如 5-氨基酮戊酸（ALA）或甲氧基 5-氨基酮戊酸（MAL）），然后用可见光或紫外线照射的过程。前体药物在靶组织中转化为光活性卟啉，当被光激活时会导致局部组织破坏。我们描述了一位 48 岁的女性患有难治性 LIS，她接受了 MAL-PDT 治疗。
