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干细胞衍生的外泌体在神经再生中的作用:对神经修复的贡献。

The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair.

机构信息

Department of Neurosurgery, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou, Guangdong, China.

Department of Orthopaedics, Chaozhou Hospital of Traditional Chinese Medicine, Chaozhou, China.

出版信息

Exp Neurol. 2024 Oct;380:114882. doi: 10.1016/j.expneurol.2024.114882. Epub 2024 Jul 23.

Abstract

Stem cell-derived exosomes have gained attention in regenerative medicine for their role in encouraging nerve regeneration and potential use in treating neurological diseases. These nanosized extracellular vesicles act as carriers of bioactive molecules, facilitating intercellular communication and enhancing the regenerative process in neural tissues. This comprehensive study explores the methods by which exosomes produced from various stem cells contribute to nerve healing, with a particular emphasis on their role in angiogenesis, inflammation, and cellular signaling pathways. By examining cutting-edge developments and exploring the potential of exosomes in delivering disease-specific miRNAs and proteins, we highlight their versatility in tailoring personalized therapeutic strategies. The findings presented here highlight the potential of stem cell-produced exosomes for use in neurological diseases therapy, establishing the door for future research into exosome-based neurotherapies.

摘要

干细胞衍生的外泌体因其在促进神经再生中的作用以及在治疗神经疾病方面的潜在用途,在再生医学领域受到关注。这些纳米大小的细胞外囊泡作为生物活性分子的载体,促进细胞间的通讯,并增强神经组织中的再生过程。本全面研究探讨了各种干细胞产生的外泌体促进神经愈合的方法,特别强调了它们在血管生成、炎症和细胞信号通路中的作用。通过检查最新的发展,并探索外泌体在递送达病特异性 miRNAs 和蛋白质方面的潜力,我们强调了它们在定制个性化治疗策略方面的多功能性。这里呈现的研究结果突出了干细胞产生的外泌体在神经疾病治疗中的应用潜力,为基于外泌体的神经治疗的未来研究奠定了基础。

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