Vocational School of Health Services, Altinbas University, 34147 Istanbul, Turkey.
Biomaterials Research Group, School of Metallurgy and Materials, College of Engineering and Physical Science, University of Birmingham, Birmingham B15 2TT, UK.
Int J Mol Sci. 2024 May 28;25(11):5863. doi: 10.3390/ijms25115863.
Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.
细胞外囊泡（EVs），包括外泌体、微泡和其他源自细胞的脂质囊泡，通过在细胞间传递信息在细胞间通讯中发挥关键作用。祖细胞和干细胞分泌的 EVs 与细胞治疗中观察到的治疗效果有关，它们也有助于损伤后的组织再生，如在矫形外科手术中。本文综述了 EVs 在神经再生中的作用、作为药物载体的潜力，以及在干细胞研究和无细胞治疗中的意义。它强调了生物工程师理解和操纵 EV 活性以优化组织工程和再生治疗效果的重要性。
