向混合餐中添加真菌蛋白会影响餐后葡萄糖动力学，而不会改变血糖浓度：一项随机对照试验。
The addition of mycoprotein to a mixed-meal impacts postprandial glucose kinetics without altering blood glucose concentrations: a randomised controlled trial.
机构信息
Department of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK.
Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Eur J Clin Nutr. 2024 Sep;78(9):757-764. doi: 10.1038/s41430-024-01470-4. Epub 2024 Jul 13.
BACKGROUND
Mycoprotein is a high-fibre food previously shown to reduce postprandial glucose concentrations when ingested within a mixed-meal. We applied a dual stable isotope tracer approach to determine whether this is due to a reduced rate of appearance of glucose, in participants of ranging BMI.
METHODS
Twenty-four adults (F = 8, BMI 30 ± 6 kg·m) attended 2 trials in a double-blind, randomised, cross-over design. Participants ingested two energy and macronutrient matched milk-based drinks (enriched with 1000 mg [U-C] glucose in a subset of 12 participants), containing 50 g glucose and either 0 (CON) or 20 g (MYC) mycoprotein. A primed continuous intravenous infusion of D-[6,6-H] glucose determined plasma glucose kinetics over 6 h. Postprandial time-course, and AUC, of glucose and insulin concentration, rate of disappearance (RdT) and appearance of exogenous (RaEx), endogenous (EGP), and total (RaT) plasma glucose were assessed using two- and one-way ANOVA.
RESULTS
Drink ingestion increased blood glucose and serum insulin concentrations (P < 0.05) and were comparable between conditions (P > 0.05). Both RaT and RdT were higher with MYC compared with CON over 6 h (mean 6 h glucose appearance and disappearance increased by 5 and 9%, respectively, P < 0.05). RaEx was not affected by MYC ingestion over 6 h (P > 0.05). The mean contribution of EGP to total glucose appearance was 15% greater with MYC, with a trend towards significance (P = 0.05). There was no relationship between BMI and the response to MYC ingestion for any of the variables (P < 0.05).
CONCLUSION
The ingestion of mycoprotein within a mixed-meal impacted postprandial glucose kinetics, but not blood glucose or serum insulin concentrations, in individuals of ranging BMI.
CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE
This trial was registered at clinicaltrials.gov as NCT04084639 and can be accessed at https://clinicaltrials.gov/ct2/show/NCT04084639 .
背景
先前的研究表明，食用高蛋白纤维的真菌蛋白可以降低混合餐餐后血糖浓度。我们采用双稳定同位素示踪法，研究这种效果是否与不同 BMI 参与者的血糖出现率降低有关。
方法
24 名成年人（F=8，BMI 30±6kg·m）参加了双盲、随机、交叉设计的 2 项试验。参与者摄入两种能量和宏量营养素匹配的牛奶饮料（在一组 12 名参与者中添加了 1000mg [U-C] 葡萄糖），含有 50g 葡萄糖和 0（CON）或 20g（MYC）真菌蛋白。通过静脉内连续输注 D-[6,6-H] 葡萄糖，6 小时内连续监测血浆葡萄糖动力学。采用双因素和单因素方差分析评估餐后时间过程和 AUC、血糖和胰岛素浓度、外源性（RaEx）、内源性（EGP）和总（RaT）血糖的消失率（RdT）。
结果
饮料摄入增加了血糖和血清胰岛素浓度（P<0.05），且两种条件下无差异（P>0.05）。与 CON 相比，MYC 组在 6 小时内的 RaT 和 RdT 均升高（6 小时葡萄糖出现和消失分别增加 5%和 9%，P<0.05）。MYC 摄入对 6 小时内的 RaEx 无影响（P>0.05）。MYC 摄入时，EGP 对总葡萄糖出现的平均贡献增加了 15%，有显著趋势（P=0.05）。对于任何变量，BMI 与 MYC 摄入的反应之间均无关系（P<0.05）。
结论
在混合餐中摄入真菌蛋白会影响餐后血糖动力学，但不会影响不同 BMI 个体的血糖或血清胰岛素浓度。
临床试验注册号和网址
本试验在 clinicaltrials.gov 上注册为 NCT04084639，可在 https://clinicaltrials.gov/ct2/show/NCT04084639 上访问。
Zotero 插件