富含血小板纤维蛋白基质联合前列腺素E-1注射对磷酸二酯酶5抑制剂难治性反应患者勃起功能的评估：一项随机安慰剂对照研究。

Evaluation of platelet-rich fibrin matrix combined with PGE-1 injection on erectile function in patients with refractory response to PDE5-I: a randomized placebo-controlled study.

作者信息

Zaazaa Adham, Eid Mohamed Abbas, GamalEl Din Sameh Fayek, Zeidan Ashraf, Hakeem Ahmed AbdEl, Farag Mohamed Abdel Fattah, Fawzy Ahmed, Kaddah Amr

机构信息

Department of Andrology, Sexology and STDs Kasr Al-Ainy, Faculty of Medicine, Cairo University, Al-Saray Street, El Manial, Cairo, 11956, Egypt.

Egypt Ministry of Health and Population, Cairo, Egypt.

出版信息

Int Urol Nephrol. 2025 Jan;57(1):27-34. doi: 10.1007/s11255-024-04139-w. Epub 2024 Jul 13.

DOI:10.1007/s11255-024-04139-w

PMID:39003366

Abstract

PURPOSE

We studied the effect of a platelet-rich fibrin matrix (PRFM) combined with prostaglandin E-1 (PGE-1) injection on erectile function in patients refractory to response for phosphodiesterase type 5 inhibitors (PDE5-Is).

METHODS

This randomized, double-blind, placebo-controlled study included 80 patients. The patients were randomly assigned to four groups and blinded together with the administrating physicians to the nature of the intracorporeal injection (ICI) therapies. Group (1) received saline, group (2) received platelet-rich fibrin matrix (PRFM), group (3) received prostaglandin E-1 (PGE-1), and group (4) received a combination of PRFM + PGE-1. The patients received ICI therapy weekly for 8 consecutive weeks. Clinical information and follow-up data were obtained at 1, 2, 3, and 6 months.

RESULTS

A significant increase occurred in the validated Arabic version of the International Index of Erectile Function (ArIIEF-5) score in group (4) compared to the other three groups (p value = 0.037). There was a significant difference in erection hardness scale (EHS) scores among all groups after receiving the different treatments (p = 0.004). A significant increase was seen in the ArIIEF-5 score in groups 4 and 3 compared to that in groups 1 and 2 (p < 0.001). There was also a significant increase in the arterial dilatation % in groups 4 and 3 compared to that in groups 1 and 2 (p = 0.019).

CONCLUSION

The combination of PRFM plus PGE-1 had shown significant improvement in the ArIIEF-5 score, yet the patients still had mild to moderate ED.

摘要

目的

我们研究了富含血小板纤维蛋白基质（PRFM）联合前列腺素E-1（PGE-1）注射对5型磷酸二酯酶抑制剂（PDE5-Is）治疗无效患者勃起功能的影响。

方法

这项随机、双盲、安慰剂对照研究纳入了80名患者。患者被随机分为四组，与给药医生一起对体内注射（ICI）治疗的性质进行盲法处理。第（1）组接受生理盐水，第（2）组接受富含血小板纤维蛋白基质（PRFM），第（3）组接受前列腺素E-1（PGE-1），第（4）组接受PRFM + PGE-1联合治疗。患者连续8周每周接受ICI治疗。在1、2、3和6个月时获取临床信息和随访数据。

结果

与其他三组相比，第（4）组国际勃起功能指数阿拉伯语有效版（ArIIEF-5）评分显著增加（p值 = 0.037）。接受不同治疗后，所有组的勃起硬度量表（EHS）评分存在显著差异（p = 0.004）。与第（1）组和第（2）组相比，第（4）组和第（3）组的ArIIEF-5评分显著增加（p < 0.001）。与第（1）组和第（2）组相比，第（4）组和第（3）组的动脉扩张百分比也显著增加（p = 0.019）。