Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, P.R. China.
School of Resources and Environmental Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P.R. China.
Environ Health. 2024 Jul 13;23(1):64. doi: 10.1186/s12940-024-01103-0.
Brominated Flame Retardants (BFRs) have attracted widespread concern due to their environmental persistence and potential toxicity. This study aims to examine the association between BFRs exposure and hypertension.
We used data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005 to 2016 for the cross-sectional analysis. To evaluate the individual and combined impacts of BFRs exposure on hypertension, we utilized multivariate models, including generalized additive models, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) models.
9882 individuals (48% male) aged ≥ 20 were included in the final analysis, of whom 4114 had hypertension. After controlling for potential covariates, higher serum concentrations of PBDE100 (OR: 1.26; 95% CI: 1.01, 1.57) and PBDE153 (OR: 1.50; 95% CI: 1.18, 1.88) were significantly associated with hypertension. A nonlinear relationship between PBDE28 and hypertension was observed (P = 0.03). Moreover, BFRs mixture were positively associated with the prevalence of hypertension in both the WQS (β:1.09; 95% CI: 1.02, 1.17; P = 0.02) and BKMR models.
Our study suggested that BFRs exposure is positively associated with hypertension in the general population. To confirm this association and elucidate the mechanisms, further research is required.
溴系阻燃剂（BFRs）因其环境持久性和潜在毒性而引起广泛关注。本研究旨在探讨 BFRs 暴露与高血压之间的关系。
我们使用了 2005 年至 2016 年国家健康和营养调查（NHANES）的数据进行横断面分析。为了评估 BFRs 暴露对高血压的个体和综合影响，我们使用了多变量模型，包括广义加性模型、加权分位数总和（WQS）回归和贝叶斯核机器回归（BKMR）模型。
最终分析纳入了 9882 名年龄≥20 岁的个体（48%为男性），其中 4114 人患有高血压。在控制了潜在的混杂因素后，血清中 PBDE100（OR：1.26；95%CI：1.01，1.57）和 PBDE153（OR：1.50；95%CI：1.18，1.88）浓度较高与高血压显著相关。观察到 PBDE28 与高血压之间存在非线性关系（P=0.03）。此外，BFRs 混合物在 WQS（β：1.09；95%CI：1.02，1.17；P=0.02）和 BKMR 模型中均与高血压的患病率呈正相关。
本研究表明，BFRs 暴露与一般人群中的高血压呈正相关。为了确认这种关联并阐明其机制，需要进一步的研究。
