Liu Junping, Liu Zhaoyue, Liu Xinru, Wang Nan, Wu Lin, Cui Yu, Wang Lu, Zhang Huanyu, Feng Yajie, Yin Xinle, Liu Yaping, Zhou Yue, Hao Yanhua, Liang Libo
School of Health Management, Harbin Medical University, Harbin, China.
School of Public Health, Fudan University, Shanghai, China.
BMC Public Health. 2025 Mar 12;25(1):980. doi: 10.1186/s12889-025-22010-0.
Environmental exposure to toxic brominated flame retardants (BFRs) has been confirmed to have detrimental effects on human health. The impact of serum BFRs on hyperlipidemia risk has not been sufficiently examined. Our objective is to identify both the individual and combined effects of serum BFRs on hyperlipidemia and to further investigate the most influential chemicals.
We included 7,009 individuals with complete details on 9 types of serum BFRs, hyperlipidemia, and other covariates from the NHANES in 2007-2016. Multivariate logistic regression was conducted to evaluate the individual impact of BFRs exposure on hyperlipidemia risk. We assessed the cumulative effect of BFRs on hyperlipidemia risk through weighted quantile sum (WQS) regression, quantile g-computation (QGC), and Bayesian kernel machine regression models.
PBDE 28, PBDE 47, PBDE 85, PBDE 99, PBDE 100, PBDE 154, PBDE 209, and PBB153 were found to be positively associated with hyperlipidemia risk. The results of WQS and QGC revealed consistent positive correlation. PBDE209 emerged as the most significant chemicals exerting influence. The restricted cubic splines regression further identified significant dose-response relationship.
Exposure to individual and combined serum BFRs has been associated with an increased risk of hyperlipidemia. The causal relationship still requires confirmation through large-scale cohort studies.
环境暴露于有毒溴化阻燃剂（BFRs）已被证实对人类健康有不利影响。血清BFRs对高脂血症风险的影响尚未得到充分研究。我们的目标是确定血清BFRs对高脂血症的个体和联合影响，并进一步调查最具影响力的化学物质。
我们纳入了2007 - 2016年美国国家健康与营养检查调查（NHANES）中7009名拥有9种血清BFRs、高脂血症及其他协变量完整详细信息的个体。进行多变量逻辑回归以评估BFRs暴露对高脂血症风险的个体影响。我们通过加权分位数和（WQS）回归、分位数g计算（QGC）和贝叶斯核机器回归模型评估BFRs对高脂血症风险的累积影响。
发现多溴二苯醚28、多溴二苯醚47、多溴二苯醚85、多溴二苯醚99、多溴二苯醚100、多溴二苯醚154、多溴二苯醚209和多溴联苯153与高脂血症风险呈正相关。WQS和QGC的结果显示出一致的正相关。多溴二苯醚209成为最具影响力的显著化学物质。受限立方样条回归进一步确定了显著的剂量反应关系。
个体和联合血清BFRs暴露与高脂血症风险增加有关。因果关系仍需通过大规模队列研究来证实。
