Esplin Kaleb C, Tsai Yi-Wen, Vela Kathryn, Diogenes Anibal, Hachem Lea El, Palaiologou Archontia, Cochran David L, Kotsakis Georgios A
Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
ITI Scholarship Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
J Periodontol. 2024 Dec;95(12):1180-1189. doi: 10.1002/JPER.23-0573. Epub 2024 Jul 14.
This study compared titanium and zirconia implant ligature-induced peri-implant defect progression and response to regenerative surgical intervention.
Eight tissue-level endosseous implants were placed in 6 mixed-breed foxhounds, with 2 zirconia and 2 titanium alternating in each hemimandible. Cotton ligatures were placed subgingivally for 16 weeks followed by 8 weeks of spontaneous progression. Standardized radiographs were captured every 2 weeks to evaluate the rate of bone loss. Regenerative surgery was performed utilizing water-jet decontamination, enamel matrix derivative, and locally harvested autogenous bone. After 16 weeks of healing, final radiographic bone levels as well as probing depths, recession, and clinical attachment levels were assessed.
All 48 implants integrated successfully. The final average post-ligature radiographic defects were 2.88 and 3.05 mm for titanium and zirconia implants, respectively. There was no significant difference between materials in the rate of radiographic bone loss (p = 0.09). Following regenerative surgery, the total average amount of radiographic bone gain was 1.41 and 1.20 mm for titanium and zirconia, respectively. The percentage of defect fill was 51.56% and 37.98% (p = 0.03) for titanium and zirconia, respectively. Inter-group differences were minimal for clinical parameters at the time of sacrifice including periodontal pocket depths (p = 0.81), recession (p = 0.98), or clinical attachment levels (p = 0.51).
No significant difference was found in the rate of peri-implant defect development between titanium and zirconia implants. Both materials gained significant radiographic bone following regenerative surgery with significantly greater defect percentage fill in titanium implants. The final clinical parameters were similar in both groups.
本研究比较了钛和氧化锆种植体结扎诱导的种植体周围缺损进展情况以及对再生性外科干预的反应。
在6只混种猎狐犬中植入8枚组织水平的骨内种植体，每侧下颌骨交替植入2枚氧化锆和2枚钛种植体。在龈下放置棉线结扎16周，随后进行8周的自然进展期。每2周拍摄标准化X线片以评估骨吸收速率。采用水刀去污、釉基质衍生物和局部采集的自体骨进行再生性手术。愈合16周后，评估最终的X线骨水平以及探诊深度、牙龈退缩和临床附着水平。
所有48枚种植体均成功植入。钛和氧化锆种植体结扎后的最终平均X线缺损分别为2.88和3.05毫米。两种材料在X线骨吸收速率上无显著差异（p = 0.09）。再生性手术后，钛和氧化锆种植体的平均X线骨增量分别为1.41和1.20毫米。钛和氧化锆种植体的缺损填充百分比分别为51.56%和37.98%（p = 0.03）。处死时两组间临床参数的组间差异极小，包括牙周袋深度（p = 0.81）、牙龈退缩（p = 0.98）或临床附着水平（p = 0.51）。
钛和氧化锆种植体周围缺损发展速率无显著差异。两种材料在再生性手术后均获得了显著的X线骨增量，钛种植体的缺损填充百分比显著更高。两组最终的临床参数相似。
