Earl U, Wells M, Bulmer J N
J Reprod Immunol. 1985 Aug;8(1):13-24. doi: 10.1016/0165-0378(85)90074-9.
The reactivity of the various trophoblast populations found in ectopic fallopian tube pregnancy with established trophoblast-reactive markers and monoclonal antibodies to MHC antigens has been studied. In ectopic tubal pregnancy fetal trophoblast shows an identical reaction pattern with these antibodies to that seen in intrauterine pregnancy, suggesting that ectopic implantation is not related to an inherent immunological abnormality of fetal trophoblast. However, from this and other studies, it appears that extravillous trophoblast displays an unusual class I MHC antigenic structure. This observation may explain the ability of class I MHC--bearing fetal trophoblast--to survive both in the uterus and at an abnormal implantation site.
对异位输卵管妊娠中发现的各种滋养层细胞群与已确定的滋养层反应性标志物及针对MHC抗原的单克隆抗体的反应性进行了研究。在异位输卵管妊娠中，胎儿滋养层细胞与这些抗体的反应模式与宫内妊娠所见相同，这表明异位着床与胎儿滋养层细胞固有的免疫异常无关。然而，从这项研究和其他研究来看，似乎绒毛外滋养层细胞表现出一种不寻常的I类MHC抗原结构。这一观察结果可能解释了携带I类MHC的胎儿滋养层细胞在子宫内和异常着床部位均能存活的能力。
