Lusaka Apex Medical University, Off Mumbwa Road, Lusaka 10101, Zambia; Pan African Organization for Health, Education and Research (POHER), United States.
Department of Radiology, Institute of Green Nanotechnology and Cancer Nanotechnology, University of Missouri, Columbia, MO 65211, USA.
Clin Res Hepatol Gastroenterol. 2024 Aug;48(7):102418. doi: 10.1016/j.clinre.2024.102418. Epub 2024 Jul 14.
Hepatocellular carcinoma (HCC) is the most frequent liver cancer, which account for more than 90 % of all liver cancer cases. It is the fifth leading cause of cancer globally and the second leading cause of cancer-related mortality in men. The availability of competent HCC preclinical models is fundamental to the success of mechanistic studies, molecular target identification, and drug testing. However, there are challenges associated with the use of these models. In this review, we provided updates on various cell lines, animals, and human HCC models, their specific preclinic use and associated potential challenges. Overall, the understanding of the merits and demerits of a particular HCC model will improve model selection for various preclinical studies.
肝细胞癌 (HCC) 是最常见的肝癌，占所有肝癌病例的 90%以上。它是全球第五大癌症死因，也是男性癌症相关死亡的第二大原因。有能力的 HCC 临床前模型对于成功进行机制研究、分子靶标识别和药物测试至关重要。然而，在使用这些模型时存在一些挑战。在这篇综述中，我们提供了各种细胞系、动物和人 HCC 模型的最新信息，以及它们在临床前的具体应用和相关的潜在挑战。总的来说，对特定 HCC 模型的优缺点的理解将提高对各种临床前研究的模型选择。
