The center of clinical laboratory, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, PR China.
Department of Reproductive Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian 364000, PR China.
Reprod Toxicol. 2024 Oct;129:108656. doi: 10.1016/j.reprotox.2024.108656. Epub 2024 Jul 14.
Bisphenol A (BPA) is a commonly used organic compound. Over the past decades, many studies have examined the mechanisms of BPA toxicity, with BPA-induced alterations in epigenetic modifications receiving considerable attention. Particularly in the male reproductive system, abnormal alterations in epigenetic markers can adversely affect reproductive function. Furthermore, these changes in epigenetic markers can be transmitted to offspring through the father. Here, we review the effects of BPA exposure on various epigenetic markers in the male reproductive system, including DNA methylation, histone modifications, and noncoding RNA, as well as associated changes in the male reproductive function. We also reviewed the effects of father's exposure to BPA on offspring epigenetic modification patterns.
双酚 A（BPA）是一种常用的有机化合物。在过去的几十年中，许多研究都探讨了 BPA 毒性的机制，其中 BPA 诱导的表观遗传修饰改变受到了相当多的关注。特别是在男性生殖系统中，表观遗传标记的异常改变会对生殖功能产生不利影响。此外，这些表观遗传标记的改变可以通过父亲传递给后代。在这里，我们综述了 BPA 暴露对男性生殖系统中各种表观遗传标记的影响，包括 DNA 甲基化、组蛋白修饰和非编码 RNA，以及男性生殖功能的相关变化。我们还回顾了父亲暴露于 BPA 对后代表观遗传修饰模式的影响。
