CEINGE-Biotecnologie Avanzate s.c.a.r.l., Naples, Italy.
Fertility Unit, Maternal-Child Department, AOU Policlinico Federico II, Naples, Italy.
Front Endocrinol (Lausanne). 2020 Jul 30;11:453. doi: 10.3389/fendo.2020.00453. eCollection 2020.
Bisphenol A (BPA) is a widespread chemical agent which can exert detrimental effects on the male reproductive system. Exposure to BPA has been shown to induce several epigenetic modifications in both animal and human cells. Specifically, BPA could not only modify the methylation pattern of multiple genes encoding proteins related to reproductive physiology but also directly influence the genes responsible for DNA methylation. BPA effects include hormonal alterations, microscopic and macroscopic alteration of male reproductive organs, and inheritable epigenetic changes involving human reproduction. BPA exposure was also linked to prostate cancer. This review aims to show the current scenario of BPA-induced epigenetic changes and its effects on the male reproductive system. Possible strategies to counter the toxic effect of BPA were also addressed.
双酚 A（BPA）是一种广泛存在的化学物质，会对男性生殖系统产生有害影响。研究表明，BPA 会在动物和人体细胞中引起多种表观遗传修饰。具体来说，BPA 不仅可以改变与生殖生理相关的多种蛋白编码基因的甲基化模式，还可以直接影响负责 DNA 甲基化的基因。BPA 的影响包括激素变化、男性生殖器官的微观和宏观改变，以及涉及人类生殖的可遗传表观遗传改变。BPA 暴露还与前列腺癌有关。本综述旨在展示 BPA 引起的表观遗传变化及其对男性生殖系统的影响的现状。还讨论了对抗 BPA 毒性作用的可能策略。
