双酚 A 诱导的表观遗传变化及其对男性生殖系统的影响。
Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System.
机构信息
CEINGE-Biotecnologie Avanzate s.c.a.r.l., Naples, Italy.
Fertility Unit, Maternal-Child Department, AOU Policlinico Federico II, Naples, Italy.
出版信息
Front Endocrinol (Lausanne). 2020 Jul 30;11:453. doi: 10.3389/fendo.2020.00453. eCollection 2020.
Abstract
Bisphenol A (BPA) is a widespread chemical agent which can exert detrimental effects on the male reproductive system. Exposure to BPA has been shown to induce several epigenetic modifications in both animal and human cells. Specifically, BPA could not only modify the methylation pattern of multiple genes encoding proteins related to reproductive physiology but also directly influence the genes responsible for DNA methylation. BPA effects include hormonal alterations, microscopic and macroscopic alteration of male reproductive organs, and inheritable epigenetic changes involving human reproduction. BPA exposure was also linked to prostate cancer. This review aims to show the current scenario of BPA-induced epigenetic changes and its effects on the male reproductive system. Possible strategies to counter the toxic effect of BPA were also addressed.
摘要
双酚 A（BPA）是一种广泛存在的化学物质，会对男性生殖系统产生有害影响。研究表明，BPA 会在动物和人体细胞中引起多种表观遗传修饰。具体来说，BPA 不仅可以改变与生殖生理相关的多种蛋白编码基因的甲基化模式，还可以直接影响负责 DNA 甲基化的基因。BPA 的影响包括激素变化、男性生殖器官的微观和宏观改变，以及涉及人类生殖的可遗传表观遗传改变。BPA 暴露还与前列腺癌有关。本综述旨在展示 BPA 引起的表观遗传变化及其对男性生殖系统的影响的现状。还讨论了对抗 BPA 毒性作用的可能策略。
相似文献
1
Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System.双酚 A 诱导的表观遗传变化及其对男性生殖系统的影响。
Front Endocrinol (Lausanne). 2020 Jul 30;11:453. doi: 10.3389/fendo.2020.00453. eCollection 2020.
2
Bisphenol A: Epigenetic effects on the male reproductive system and male offspring.双酚 A：对男性生殖系统和雄性后代的表观遗传效应。
Reprod Toxicol. 2024 Oct;129:108656. doi: 10.1016/j.reprotox.2024.108656. Epub 2024 Jul 14.
3
Bisphenols and Leydig Cell Development and Function.双酚类物质与莱迪希细胞的发育和功能。
Front Endocrinol (Lausanne). 2020 Jul 31;11:447. doi: 10.3389/fendo.2020.00447. eCollection 2020.
4
Bisphenol A in Reproduction: Epigenetic Effects.双酚A在生殖中的作用：表观遗传效应。
Curr Med Chem. 2018 Feb 21;25(6):748-770. doi: 10.2174/0929867324666171009121001.
5
Endocrine disrupting chemical Bisphenol A and its potential effects on female health.内分泌干扰化学物质双酚 A 及其对女性健康的潜在影响。
Diabetes Metab Syndr. 2021 May-Jun;15(3):803-811. doi: 10.1016/j.dsx.2021.03.031. Epub 2021 Mar 31.
6
Effects of BPA on female reproductive function: The involvement of epigenetic mechanism.双酚A对雌性生殖功能的影响：表观遗传机制的作用。
Gen Comp Endocrinol. 2017 May 1;245:122-126. doi: 10.1016/j.ygcen.2016.08.010. Epub 2016 Aug 30.
7
Epigenetic modifications associated with in utero exposure to endocrine disrupting chemicals BPA, DDT and Pb.与宫内暴露于内分泌干扰化学物质 BPA、DDT 和 Pb 相关的表观遗传修饰。
Rev Environ Health. 2019 Dec 18;34(4):309-325. doi: 10.1515/reveh-2018-0059.
8
Could the endocrine disruptor bisphenol-A be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions.内分泌干扰物双酚 A 是否与口腔和口咽癌的发病机制有关？代谢方面的考虑因素和未来方向。
Metabolism. 2019 Feb;91:61-69. doi: 10.1016/j.metabol.2018.11.007. Epub 2018 Nov 17.
9
Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.产前暴露于双酚 A 会破坏肥胖相关基因 fggy 近端启动子处自然发生的双峰 DNA 甲基化，fggy 编码一种碳水化合物激酶，存在于 CD-1 小鼠的性腺白色脂肪组织中。
Endocrinology. 2018 Feb 1;159(2):779-794. doi: 10.1210/en.2017-00711.
10
Epigenetic perspective on the developmental effects of bisphenol A.双酚 A 对发育影响的表观遗传学观点。
Brain Behav Immun. 2011 Aug;25(6):1084-93. doi: 10.1016/j.bbi.2011.02.005. Epub 2011 Feb 17.
引用本文的文献
1
The Chromatin Configuration Promotes Constitutional Chromosomal Rearrangements in Post-Meiotic Sperm.染色质构型促进减数分裂后精子中的先天性染色体重排。
Methods Mol Biol. 2025;2968:549-556. doi: 10.1007/978-1-0716-4750-9_33.
2
Case Report: Toxic tubulointerstitial nephropathy with lipofuscin deposition - the potential cause of occupational Bisphenol-A exposition.病例报告：伴有脂褐素沉积的中毒性肾小管间质性肾病——职业性双酚A暴露的潜在原因。
Pathol Oncol Res. 2025 Jul 7;31:1612046. doi: 10.3389/pore.2025.1612046. eCollection 2025.
3
Effect of Endocrine Disruptors on Testicular Function.内分泌干扰物对睾丸功能的影响。
Adv Exp Med Biol. 2025;1469:115-125. doi: 10.1007/978-3-031-82990-1_6.
4
Stable Transmission of DNA Methylation Epimutations from Germlines to the Liver and Their Association with Fatty Liver Disease in Medaka.DNA甲基化表观突变从生殖系到肝脏的稳定传递及其与青鳉脂肪肝疾病的关联
Res Sq. 2025 Feb 14:rs.3.rs-6010210. doi: 10.21203/rs.3.rs-6010210/v1.
5
Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake.内分泌干扰化学物质在乳腺癌中的表观遗传机制及其对饮食摄入的影响。
J Xenobiot. 2024 Dec 24;15(1):1. doi: 10.3390/jox15010001.
6
Impact of Bisphenol A and its alternatives on oocyte health: a scoping review.双酚 A 及其替代品对卵母细胞健康的影响：范围综述。
Hum Reprod Update. 2024 Dec 1;30(6):653-691. doi: 10.1093/humupd/dmae025.
7
Exposure characteristics and cumulative risk assessment of bisphenol A and its substitutes: the Taiwan environmental survey for toxicants 2013.双酚 A 及其替代品的暴露特征和累积风险评估：2013 年台湾毒物环境监测。
Front Public Health. 2024 May 23;12:1396147. doi: 10.3389/fpubh.2024.1396147. eCollection 2024.
8
Survey on the Environmental Risks of Bisphenol A and Its Relevant Regulations in Taiwan: An Environmental Endocrine-Disrupting Chemical of Increasing Concern.台湾地区双酚A的环境风险及其相关法规调查：一种日益受到关注的环境内分泌干扰化学物质。
Toxics. 2023 Aug 23;11(9):722. doi: 10.3390/toxics11090722.
9
The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A.双酚 A 的表观遗传效应的研究现状和证据权重。
Int J Mol Sci. 2023 Apr 27;24(9):7951. doi: 10.3390/ijms24097951.
10
Unlocking the mystery associated with infertility and prostate cancer: an update.揭开与不孕症和前列腺癌相关的谜团：最新进展。
Med Oncol. 2023 Apr 26;40(6):160. doi: 10.1007/s12032-023-02028-3.
本文引用的文献
1
Taurine effects on Bisphenol A-induced oxidative stress in the mouse testicular mitochondria and sperm motility.牛磺酸对双酚 A 诱导的小鼠睾丸线粒体氧化应激及精子运动能力的影响。
JBRA Assist Reprod. 2020 Oct 6;24(4):428-435. doi: 10.5935/1518-0557.20200017.
2
Bisphenol A: an emerging threat to female fertility.双酚 A：女性生育力面临的新威胁。
Reprod Biol Endocrinol. 2020 Mar 14;18(1):22. doi: 10.1186/s12958-019-0558-8.
3
Genome-Wide Analysis of Low Dose Bisphenol-A (BPA) Exposure in Human Prostate Cells.人前列腺细胞中低剂量双酚A（BPA）暴露的全基因组分析
Curr Genomics. 2019 May;20(4):260-274. doi: 10.2174/1389202920666190603123040.
4
Cuscuta chinensis flavonoids down-regulate the DNA methylation of the H19/Igf2 imprinted control region and estrogen receptor alpha promoter of the testis in bisphenol A exposed mouse offspring.菟丝子黄酮下调双酚 A 暴露子代小鼠睾丸中 H19/Igf2 印迹控制区和雌激素受体α启动子的 DNA 甲基化。
Food Funct. 2020 Jan 29;11(1):787-798. doi: 10.1039/c9fo02770j.
5
Protective Action of Leaves Aqueous Extracts Against Bisphenol A-Caused Testicular Damages.叶片水提物对双酚 A 引起的睾丸损伤的保护作用。
J Med Food. 2020 Jun;23(6):600-610. doi: 10.1089/jmf.2019.0170. Epub 2019 Dec 20.
6
Epigenetic analysis of high and low motile sperm populations reveals methylation variation in satellite regions within the pericentromeric position and in genes functionally related to sperm DNA organization and maintenance in Bos taurus.高、低游动精子群体的表观遗传分析揭示了牛基因组着丝粒位置卫星区域以及与精子 DNA 组织和维持功能相关基因中的甲基化变异。
BMC Genomics. 2019 Dec 6;20(1):940. doi: 10.1186/s12864-019-6317-6.
7
Genetic and epigenetic alterations induced by bisphenol A exposure during different periods of spermatogenesis: from spermatozoa to the progeny.双酚 A 在精子发生不同时期暴露所诱导的遗传和表观遗传改变：从精子到后代。
Sci Rep. 2019 Dec 2;9(1):18029. doi: 10.1038/s41598-019-54368-8.
8
Oxidative Stress and DNA methylation in male rat pups provoked by the transplacental and translactational exposure to bisphenol A.双酚 A 通过胎盘和乳转暴露对雄性幼鼠引发的氧化应激和 DNA 甲基化。
Environ Sci Pollut Res Int. 2020 Feb;27(4):4513-4519. doi: 10.1007/s11356-019-06553-5. Epub 2019 Nov 26.
9
Gcn5-Mediated Histone Acetylation Governs Nucleosome Dynamics in Spermiogenesis.Gcn5 介导的组蛋白乙酰化在精子发生中控制核小体动力学。
Dev Cell. 2019 Dec 16;51(6):745-758.e6. doi: 10.1016/j.devcel.2019.10.024. Epub 2019 Nov 21.
10
Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells.双酚 A 在人前列腺癌细胞中的全球和区域特异性转录后和翻译后修饰。
Environ Pollut. 2019 Dec;255(Pt 2):113318. doi: 10.1016/j.envpol.2019.113318. Epub 2019 Oct 2.
Zotero 插件