China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Environ Res. 2024 Nov 1;260:119612. doi: 10.1016/j.envres.2024.119612. Epub 2024 Jul 14.
Fish consumption can increase purine load in human body, and the enrichment of mercury in fish may affect the glomerular filtration function, both resulting in increased serum uric acid (SUA) levels. The data of blood mercury (BHg), fish consumption frequency and SUA levels of 7653 participants aged 18 years or older was from China National Human Biomonitoring (2017-2018). The associations between fish consumption frequency, ln-transformed BHg and SUA levels were explored through weighted multiple linear regressions. The mediating effect of BHg levels between fish consumption frequency and SUA levels was evaluated by mediation analysis. We found that both the fish consumption frequency and BHg were positively associated with SUA levels in both sexes. Compared to participants who had never consumed fish, participants who consumed fish once a week or more had higher SUA levels [β (95% confidence interval, CI): 20.39 (2.16, 38.62) in males; β (95% CI): 10.06 (0.76, 19.37) in females] and ln-transformed BHg [β (95% CI): 0.97 (0.61, 1.34) in males; β (95% CI): 0.84 (0.63, 1.05) in females]. Each 1-unit increase in ln-transformed BHg, the SUA levels rose by 4.78 (95% CI: 0.01, 9.54) μmol/L for males and 3.81 (95% CI: 1.60, 6.03) μmol/L for females. The association between fish consumption with SUA levels was mediated by ln-transformed BHg with the percent mediated of 34.66% in males and 26.58% in females. It revealed that BHg played mediating roles in the elevation of SUA levels caused by fish consumption. This study's findings could promote the government to intervene in mercury pollution in fish, so as to ensure the safety of fish consumption.
鱼类消费会增加人体内的嘌呤负荷，而鱼类中汞的富集可能会影响肾小球滤过功能，这两者都会导致血清尿酸（SUA）水平升高。本研究的数据来自于中国国家人群生物监测（2017-2018 年），共纳入了 7653 名年龄在 18 岁及以上的参与者的血汞（BHg）、鱼类消费频率和 SUA 水平的数据。通过加权多重线性回归探讨了鱼类消费频率、ln 转化 BHg 与 SUA 水平之间的关系。通过中介分析评估了 BHg 水平在鱼类消费频率与 SUA 水平之间的中介作用。我们发现，鱼类消费频率和 BHg 与两性 SUA 水平均呈正相关。与从不食用鱼类的参与者相比，每周至少食用一次鱼类的参与者的 SUA 水平更高[男性：β（95%置信区间，CI）：20.39（2.16，38.62）；女性：β（95%CI）：10.06（0.76，19.37）]，ln 转化的 BHg 水平更高[男性：β（95%CI）：0.97（0.61，1.34）；女性：β（95%CI）：0.84（0.63，1.05）]。ln 转化的 BHg 每增加 1 个单位，男性的 SUA 水平升高 4.78（95%CI：0.01，9.54）μmol/L，女性的 SUA 水平升高 3.81（95%CI：1.60，6.03）μmol/L。鱼类消费与 SUA 水平之间的关联由 ln 转化的 BHg 介导，男性的中介百分比为 34.66%，女性的中介百分比为 26.58%。结果表明，在鱼类消费引起的 SUA 水平升高中，BHg 发挥了中介作用。本研究结果可以促使政府干预鱼类中的汞污染，以确保鱼类消费的安全性。
