Department of Gastroenterology, The Third People's Hospital of Kunshan, Kunshan, China.
Endoscopy Center, The First People's Hospital of Kunshan, Kunshan, China.
PLoS One. 2023 Oct 13;18(10):e0287352. doi: 10.1371/journal.pone.0287352. eCollection 2023.
Dietary factors has been found to influence serum uric acid (SUA) levels. We further explored the associations between dietary and supplemental vitamin C intake and SUA in a large population-based study.
The cross-sectional study included 6308 participants (3146 males and 3162 females) aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 in the United States. The dietary vitamin C was log-transformed for statistical analysis. Hyperuricemia was defined as SUA concentrations >420 umol/L in males or >360 umol/L in females. The associations of dietary vitamin C and supplemental vitamin C with SUA levels and hyperuricemia risk were evaluated using weighted linear regression models and weighted multivariate logistic regression models, and a subgroup analysis stratified by gender was also conducted.
In this large-scale database study, there was a negative association between dietary vitamin C (log transformed) and SUA levels in US adults (β = -7.27, 95% CI: -11.58, -2.97). The inverse relationship existed among males but not females (P for interaction = 0.02). There was inverse correlation between dietary vitamin C (log transformed) and hyperuricemia risk (OR = 0.68, 95% CI: 0.57, 0.81), especially in males compared to females determined through an interaction test (P = 0.04). There were no associations between supplemental vitamin C and SUA levels (β = 1.00 (95% CI: -4.44, 6.44) or hyperuricemia risk (OR = 0.98 (95% CI: 0.78, 1.24). High-dosage supplemental vitamin C (>300 mg) and hyperuricemia risk were not associated (OR = 1.04, 95% CI: 0.69, 1.56).
This study demonstrated that there were negative associations between dietary vitamin C and SUA levels and hyperuricemia risk among US adults. The inverse correlations between dietary vitamin C and hyperuricemia risk were more significant in males compared to females. There were no associations between supplemental vitamin C and SUA levels or hyperuricemia risk.
饮食因素已被发现会影响血清尿酸（SUA）水平。我们在一项大型基于人群的研究中进一步探讨了饮食和补充维生素 C 摄入量与 SUA 之间的关系。
这项横断面研究纳入了美国国家健康和营养检查调查（NHANES）2011-2016 年的 6308 名年龄≥20 岁的参与者（男性 3146 名，女性 3162 名）。为了进行统计分析，对饮食中的维生素 C 进行了对数转换。高尿酸血症定义为男性 SUA 浓度>420 μmol/L 或女性>360 μmol/L。使用加权线性回归模型和加权多变量 logistic 回归模型评估饮食维生素 C 和补充维生素 C 与 SUA 水平和高尿酸血症风险之间的关系，并按性别进行亚组分析。
在这项大规模数据库研究中，美国成年人的饮食维生素 C（对数转换）与 SUA 水平呈负相关（β=-7.27，95%CI：-11.58，-2.97）。这种负相关关系仅存在于男性，而不存在于女性（交互检验 P=0.02）。饮食维生素 C（对数转换）与高尿酸血症风险呈负相关（OR=0.68，95%CI：0.57，0.81），尤其是通过交互检验确定的男性与女性之间（P=0.04）。补充维生素 C 与 SUA 水平（β=1.00（95%CI：-4.44，6.44）或高尿酸血症风险（OR=0.98（95%CI：0.78，1.24）之间无关联。高剂量补充维生素 C（>300mg）与高尿酸血症风险无关（OR=1.04，95%CI：0.69，1.56）。
本研究表明，美国成年人饮食维生素 C 与 SUA 水平和高尿酸血症风险呈负相关。饮食维生素 C 与高尿酸血症风险之间的负相关关系在男性中比女性更为显著。补充维生素 C 与 SUA 水平或高尿酸血症风险之间无关联。
