Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Division of Nephropathology, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Adv Kidney Dis Health. 2024 May;31(3):246-254. doi: 10.1053/j.akdh.2024.01.001.
The nephritic syndrome has been associated with a wide variety of infections, spanning many organisms and myriad clinical presentations. Infection-associated glomerulonephritis is challenging to diagnose given the many confounding factors linking kidney injury to infection; however, urine microscopy can assist in identifying abnormal cellular elements suggestive of glomerulonephritis. Kidney biopsy remains the gold standard for diagnosing the underlying pathologic lesion. Treatment of infection-associated glomerulonephritis centers around aggressive and complete treatment of the underlying infectious driver. It is often hard to know exactly when immunosuppression may be required in addition to treating the infection.
肾病综合征与多种感染相关,涉及多种病原体和多种临床表现。由于将肾脏损伤与感染联系起来的因素众多,感染相关性肾小球肾炎的诊断具有挑战性;然而,尿液显微镜检查有助于识别提示肾小球肾炎的异常细胞成分。肾活检仍然是诊断潜在病理病变的金标准。感染相关性肾小球肾炎的治疗侧重于积极和彻底治疗潜在的感染驱动因素。除了治疗感染之外,何时可能需要免疫抑制往往很难确切知道。