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双相情感障碍中的昼夜节律相位不稳定：一个被忽视的本质。

Circadian phase instability in bipolar disorder: a neglected essence.

作者信息

Romo-Nava Francisco

机构信息

Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

出版信息

Trends Mol Med. 2025 Jan;31(1):7-10. doi: 10.1016/j.molmed.2024.06.012. Epub 2024 Jul 14.

DOI:10.1016/j.molmed.2024.06.012
PMID:39004549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11717640/
Abstract

Circadian system disruption is an essential but poorly understood feature of bipolar disorder (BD) and associated comorbidities. This forum article summarizes current evidence regarding the emerging concept of circadian phase instability (CPI) as a neglected phenomenon with possibly unique features in BD that could be harnessed to develop individually tailored chronobiological interventions.

摘要

昼夜节律系统紊乱是双相情感障碍（BD）及其相关共病的一个重要但尚未被充分理解的特征。这篇论坛文章总结了当前关于昼夜节律相位不稳定（CPI）这一新兴概念的证据，CPI是BD中一个被忽视的现象，可能具有独特特征，可用于开发个性化的时间生物学干预措施。