The Key Laboratory of Industrial Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.
World J Microbiol Biotechnol. 2024 Jul 15;40(9):267. doi: 10.1007/s11274-024-04066-z.
As an efficient and safe industrial bacterium, Corynebacterium glutamicum has extensive application in amino acid production. However, it often faces oxidative stress induced by reactive oxygen species (ROS), leading to diminished production efficiency. To enhance the robustness of C. glutamicum, numerous studies have focused on elucidating its regulatory mechanisms under various stress conditions such as heat, acid, and sulfur stress. However, a comprehensive review of its defense mechanisms against oxidative stress is needed. This review offers an in-depth overview of the mechanisms C. glutamicum employs to manage oxidative stress. It covers both enzymatic and non-enzymatic systems, including antioxidant enzymes, regulatory protein families, sigma factors involved in transcription, and physiological redox reduction pathways. This review provides insights for advancing research on the antioxidant mechanisms of C. glutamicum and sheds light on its potential applications in industrial production.
作为一种高效且安全的工业细菌，谷氨酸棒杆菌在氨基酸生产中有着广泛的应用。然而，它经常面临活性氧（ROS）引起的氧化应激，导致生产效率降低。为了提高谷氨酸棒杆菌的鲁棒性，许多研究集中在阐明其在各种应激条件下的调控机制，如热、酸和硫应激。然而，需要对其抗氧化应激的防御机制进行全面的综述。本文深入综述了谷氨酸棒杆菌应对氧化应激的机制。它涵盖了酶和非酶系统，包括抗氧化酶、调节蛋白家族、参与转录的σ因子以及生理氧化还原途径。本文的综述为深入研究谷氨酸棒杆菌的抗氧化机制提供了参考，并为其在工业生产中的潜在应用提供了启示。
