Division of Hematology/Oncology, Texas Children's Hospital, Houston, Texas, USA.
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Pediatr Blood Cancer. 2024 Oct;71(10):e31194. doi: 10.1002/pbc.31194. Epub 2024 Jul 14.
Sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are two uncommon disorders each characterized by multisystemic manifestations. Individuals with SCD exhibit abnormalities in the complement pathway, which may predispose patients to develop autoimmune disorders such as SLE. As many manifestations of SLE mimic those of SCD, diagnosis and therapeutic management of SLE in a patient with known SCD may be delayed. In this study, we describe our institutional experience of diagnosing and managing concomitant SCD and SLE. We offer insights into the complex interplay between these conditions to enhance early recognition and effective management of concurrent SCD and SLE.
镰状细胞病（SCD）和系统性红斑狼疮（SLE）是两种罕见的疾病，每种疾病都以多系统表现为特征。SCD 患者的补体途径存在异常，这可能使患者易患 SLE 等自身免疫性疾病。由于 SLE 的许多表现类似于 SCD，因此在已知患有 SCD 的患者中诊断和治疗 SLE 可能会被延迟。在这项研究中，我们描述了我们在诊断和治疗同时患有 SCD 和 SLE 的患者方面的机构经验。我们深入探讨了这些疾病之间的复杂相互作用，以提高对同时患有 SCD 和 SLE 的患者的早期识别和有效管理。
