Ma Jinlu, Zhang Lin, Yan Mengxue, Liu Zhichun, Xue Leixi
Department of Rheumatology and Immunology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
Immun Inflamm Dis. 2025 Apr;13(4):e70201. doi: 10.1002/iid3.70201.
Thrombocytopenia is a common clinical manifestation of Systemic lupus erythematosus (SLE), and platelets may play a central role in the pathogenesis of immune-mediated inflammatory diseases. The study aimed to investigate the relationship between platelet count and clinical manifestations and serologic markers in systemic lupus erythematosus (SLE).
This single-center retrospective study extracted demographic data, blood cell counts, complement (C) levels, autoantibody profiles, and clinical presentation information from the electronic medical records of patients with SLE. The SLE Disease Activity Index 2000 (SLEDAI 2000) score was calculated, and Spearman's correlation coefficient was used to evaluate the correlation between platelet count and other variables.
A total of 418 patients with SLE were included in the study. The platelet count was correlated with hemoglobin, complement 3 (C3), and C4 levels; leukocyte, neutrophil, and lymphocyte counts; and the SLEDAI 2000 score. In patients with SLE with thrombocytopenia, the platelet count was associated with the hemoglobin level and a positive direct Coombs' test. The platelet count in patients with SLE without thrombocytopenia was significantly lower compared with the healthy controls, and the platelet count in this group was correlated with C3 and C4 levels, as well as the leukocyte, neutrophil, and lymphocyte counts. The disease characteristics of patients with SLE with thrombocytopenia differed from those of patients with SLE without thrombocytopenia, whereas the clinical features were essentially the same between patients with mild to moderate SLE-associated thrombocytopenia and patients with severe SLE-associated thrombocytopenia.
Patients with SLE can be categorized into two groups with different clinical features based on the presence or absence of thrombocytopenia. Furthermore, the platelet count correlates with other blood cell counts and complement levels, particularly in patients with SLE without thrombocytopenia.
血小板减少是系统性红斑狼疮（SLE）常见的临床表现，血小板可能在免疫介导的炎症性疾病发病机制中起核心作用。本研究旨在探讨系统性红斑狼疮（SLE）患者血小板计数与临床表现及血清学标志物之间的关系。
本单中心回顾性研究从SLE患者的电子病历中提取人口统计学数据、血细胞计数、补体（C）水平、自身抗体谱和临床表现信息。计算SLE疾病活动指数2000（SLEDAI 2000）评分，采用Spearman相关系数评估血小板计数与其他变量之间的相关性。
共纳入418例SLE患者。血小板计数与血红蛋白、补体3（C3）和C4水平；白细胞、中性粒细胞和淋巴细胞计数；以及SLEDAI 2000评分相关。在SLE合并血小板减少的患者中，血小板计数与血红蛋白水平及直接抗人球蛋白试验阳性相关。SLE无血小板减少患者的血小板计数与健康对照相比显著降低，该组血小板计数与C3和C4水平以及白细胞、中性粒细胞和淋巴细胞计数相关。SLE合并血小板减少患者的疾病特征与SLE无血小板减少患者不同，而轻度至中度SLE相关性血小板减少患者与重度SLE相关性血小板减少患者的临床特征基本相同。
根据是否存在血小板减少，SLE患者可分为两组，具有不同的临床特征。此外，血小板计数与其他血细胞计数和补体水平相关，特别是在无血小板减少的SLE患者中。
