Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
State Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan, Shandong, 250012, China.
Curr Gene Ther. 2024;24(5):347-355. doi: 10.2174/0115665232291010240221104445.
Hepatocyte growth factor (HGF) is expressed in multiple systems and mediates a variety of biological activities, such as mitosis, motility, and morphogenesis. A growing number of studies have revealed the expression patterns and functions of HGF in ovarian and testicular physiology from the prenatal to the adult stage. HGF regulates folliculogenesis and steroidogenesis by modulating the functions of theca cells and granulosa cells in the ovary. It also mediates somatic cell proliferation and steroidogenesis, thereby affecting spermatogenesis in males. In addition to its physiological effects on the reproductive system, HGF has shown advantages in preclinical studies over recent years for the treatment of male and female infertility, particularly in women with premature ovarian insufficiency. This review aims to summarize the pleiotropic functions of HGF in the reproductive system and to provide prospects for its clinical application.
肝细胞生长因子 (HGF) 在多个系统中表达，并介导多种生物学活性，如有丝分裂、运动和形态发生。越来越多的研究揭示了 HGF 在卵巢和睾丸生理学中的表达模式和功能，从产前到成年阶段。HGF 通过调节卵巢中膜细胞和颗粒细胞的功能来调节卵泡发生和类固醇生成。它还介导体细胞增殖和类固醇生成，从而影响男性的精子发生。除了对生殖系统的生理作用外，近年来，HGF 在治疗男性和女性不孕，特别是在卵巢早衰的女性中的临床前研究中显示出优势。本综述旨在总结 HGF 在生殖系统中的多效性功能，并为其临床应用提供前景。
