Liu Lin, Xi Xue-Na, Huang Tao, Han Guo-Liang
Department of Stomatology, Hengshui People's Hospital (Harrison International Peace Hospital). Hengshui 053000, Hebei Province, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2024 Apr;33(2):175-179.
To explore the therapeutic effect of stromal cell derived factor-1α(SDF-1α) combined with platelet-poor plasma(PPP) on permanent tooth avulsion injury.
One hundred and forty-four patients with permanent tooth avulsion injuries admitted to Hengshui People's Hospital from March 2020 to March 2022, with a total of 152 affected teeth were included. They were randomly divided into experimental group of 72 cases(76 teeth) and control group of 72 cases(76 teeth). The control group underwent routine replantation surgery, and the root tips were soaked and rinsed with PPP biological solution before surgery. On the basis of the control group, the experimental group implanted SDF-1α into the alveolar fossa before in vitro tooth implantation for treatment. The patients were followed up for 12 months after surgery, the success rate of implantation, degree of postoperative occlusal pain, expression of inflammatory factors in gingival fluid, serum growth factor expression, and incidence of postoperative complications were compared between the two groups. Statistical analysis was performed with SPSS 19.0 software package.
The success rate of replantation in the control group was 90.79%(69/76), while the experimental group was 98.68%(75/76). The success rate of replantation in the experimental group was significantly higher than that in the control group(P＜0.05). On the 2nd day, 3 months and 12 months after surgery, the pain scores of the two groups of patients gradually decreased (P＜0.05). There was no significant difference in pain scores between the two groups at each time point(P＞0.05). One month after surgery, the CRP and IL-6 levels in both groups decreased(P＜0.05), while the experimental group was significantly lower than the control group(P＜0.05). The soluble intercellular adhesion factor (sICAM-1) in both groups increased, and the experimental group was significantly higher than the control group (P＜0.05). One month after surgery, vascular endothelial growth factor(VEGF), fibroblast growth factor(FGF), transforming growth factor beta(TGF-β)and platelet derived growth factor(PDGF) were all elevated, and the experimental group was significantly higher than the control group(P＜0.05). The incidence of postoperative complications in the experimental group was significantly lower than that in the control group(P＜0.05).
The combination of PPP and SDF-1α in treating patients with permanent tooth avulsion injury has a high success rate of delayed replantation and a low incidence of postoperative adverse reactions.
探讨基质细胞衍生因子-1α（SDF-1α）联合乏血小板血浆（PPP）对恒牙脱位伤的治疗效果。
选取2020年3月至2022年3月在衡水市人民医院收治的144例恒牙脱位伤患者，共152颗患牙。将其随机分为实验组72例（76颗牙）和对照组72例（76颗牙）。对照组行常规再植术，术前用PPP生物溶液浸泡冲洗根尖。实验组在对照组基础上，于体外植牙前向牙槽窝内植入SDF-1α进行治疗。术后对患者随访12个月，比较两组的种植成功率、术后咬合痛程度、龈沟液中炎症因子表达、血清生长因子表达及术后并发症发生率。采用SPSS 19.0软件包进行统计学分析。
对照组再植成功率为90.79%（69/76），实验组为98.68%（75/76）。实验组再植成功率显著高于对照组（P＜0.05）。术后第2天、3个月和12个月，两组患者疼痛评分逐渐降低（P＜0.05）。各时间点两组疼痛评分比较差异无统计学意义（P＞0.05）。术后1个月，两组C反应蛋白（CRP）和白细胞介素-6（IL-6）水平均降低（P＜0.05），但实验组显著低于对照组（P＜0.05）。两组可溶性细胞间黏附因子（sICAM-1）均升高，且实验组显著高于对照组（P＜0.05）。术后1个月，血管内皮生长因子（VEGF）、成纤维细胞生长因子（FGF）、转化生长因子β（TGF-β）和血小板衍生生长因子（PDGF）均升高，且实验组显著高于对照组（P＜0.05）。实验组术后并发症发生率显著低于对照组（P＜0.05）。
PPP联合SDF-1α治疗恒牙脱位伤患者，延期再植成功率高，术后不良反应发生率低。
