Sárik Julián Robin, Hetényi Anasztázia, Berkecz Róbert, Szatmári István, Lőrinczi Bálint
Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6 H-6720 Szeged Hungary
Department of Medical Chemistry, University of Szeged Dóm tér 8 H-6720 Szeged Hungary.
RSC Adv. 2024 Jul 12;14(31):22123-22131. doi: 10.1039/d4ra04341c.
Lactam formation of different KYNA amides and Mannich bases mediated by -quinone methide has been investigated. The efficiency of the two routes of the cyclization process was revealed and the influence of diverse amide side chains was explored. In this regard compounds bearing a tertiary amine function in the amide side chain resulted in the formation of the lactam product, while the formation of dimer derivatives was observed in the case of other KYNA amides. Furthermore, derivatives bearing different substituents on the KYNA B ring were synthesized and their effects on the ring-closure reaction were investigated.
研究了由醌甲基化物介导的不同犬尿喹啉酸酰胺和曼尼希碱的内酰胺形成。揭示了环化过程两条路线的效率，并探索了不同酰胺侧链的影响。在这方面，酰胺侧链带有叔胺官能团的化合物导致内酰胺产物的形成，而在其他犬尿喹啉酸酰胺的情况下观察到二聚体衍生物的形成。此外，合成了在犬尿喹啉酸B环上带有不同取代基的衍生物，并研究了它们对闭环反应的影响。
