尼日利亚中北部乔斯大学教学医院赞科综合健康中心蛇（锯鳞蝰）咬伤个体中毒对血清肝脏生物标志物的影响

Effect of Envenomation on Serum Hepatic Biomarkers in Snake (Echis Ocellatus) Bitten Individuals in Zamko Comprehensive Health Centre of the Jos University Teaching Hospital, North Central Nigeria.

作者信息

Longwap Abdulazis, Emmanuel Innocent, Affi Ayuba, Imoh Lucius, Mbwas Mashor, Dajel Titus, Bawa Ibrahim, Sani Adamu, Akpagher Fredrick, Odo Alfred, Isichei Christian, Ajang Yakubu, Adebisi Simeon, Salihu Fatima

机构信息

Department of Chemical Pathology, University of Jos, Jos, Nigeria.

Department of Histopathology, University of Jos, Jos, Nigeria.

出版信息

Niger Med J. 2024 May 23;65(2):142-152. doi: 10.60787/nmj-v65i2-353. eCollection 2024 Mar-Apr.

DOI:10.60787/nmj-v65i2-353

PMID:39005559

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240208/

Abstract

BACKGROUND

Snake bite is a neglected public health issue in many tropical and subtropical countries of the world. About 5.4 million snakebites occur each year, resulting in 1.8 to 2.7 million cases of envenomation yearly. Hepatic markers have been reported to rise 3-6 hours after injection of venom in experimental animals. This study aims to biochemically assess ALT, AST and GGT levels as biomarkers of Echis ocellatus envenomation in victims of snake bite presenting at JUTH Comprehensive Health Centre Zamko 6hours post-bite and compare with values in those bitten by non-venomous snakes.

METHODOLOGY

The study was a comparative cross-sectional study where serum levels of AST, ALT and GGT were compared between the study group and the control group.

RESULTS

Of the 150 respondents, 75 from each study group, 90(60.0%) were Male while 60(40.0%) were Female, with a Male to Female ratio of 1.5:1. The most predominant age group was 20-29 years 57(38.0%), the mean age was 39 years. The most predominant occupation was farming 82(54.7%). The majority 82(54.7%) had a secondary level of education. 91(60.7%) were married. A large majority of 123(82.0) had Christianity as their religion. We found a significant increase in the levels of AST (47.45IU/L) and GGT (61.62 IU/L) in the study group compared to AST (25.88IU/L), GGT (29.61IU/L) in the control group at p<0.05, while the level of ALT was similar in both groups at p>0.05.

CONCLUSION

This implies that serum levels of AST and GGT can be used to diagnose envenomation in snakebite patients.

摘要

背景

在世界上许多热带和亚热带国家，蛇咬伤是一个被忽视的公共卫生问题。每年约发生540万次蛇咬伤事件，每年导致180万至270万例蛇毒中毒病例。据报道，在实验动物中注射毒液后3 - 6小时肝脏标志物会升高。本研究旨在对在扎姆科朱思综合健康中心咬伤6小时后就诊的蛇咬伤受害者的谷丙转氨酶（ALT）、谷草转氨酶（AST）和γ-谷氨酰转移酶（GGT）水平进行生化评估，将其作为锯鳞蝰蛇毒中毒的生物标志物，并与被无毒蛇咬伤者的值进行比较。

方法

该研究为比较性横断面研究，比较了研究组和对照组血清中AST、ALT和GGT的水平。

结果

在150名受访者中，每个研究组75人，男性90人（60.0%），女性60人（40.0%），男女比例为1.5:1。最主要的年龄组是20 - 29岁，有57人（38.0%），平均年龄为39岁。最主要的职业是务农，有82人（54.7%）。大多数人82人（54.7%）接受过中等教育。91人（60.7%）已婚。绝大多数123人（82.0%）的宗教信仰是基督教。我们发现，与对照组的AST（25.88IU/L）、GGT（29.61IU/L）相比，研究组的AST（47.45IU/L）和GGT（61.62IU/L）水平显著升高，p<0.05，而两组的ALT水平相似，p>0.05。