自身免疫性疾病与长期新冠的孟德尔随机化和贝叶斯模型平均法
Mendelian randomization and Bayesian model averaging of autoimmune diseases and Long COVID.
作者信息
Feng Jieni, Chen Jiankun, Li Xiaoya, Ren Xiaolei, Chen Junxu, Li Zuming, Wu Yuan, Zhang Zhongde, Yang Rongyuan, Li Jiqiang, Lu Yue, Liu Yuntao
机构信息
The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, Guangzhou, China.
出版信息
Front Genet. 2024 Jun 20;15:1383162. doi: 10.3389/fgene.2024.1383162. eCollection 2024.
BACKGROUND
Following COVID-19, reports suggest Long COVID and autoimmune diseases (AIDs) in infected individuals. However, bidirectional causal effects between Long COVID and AIDs, which may help to prevent diseases, have not been fully investigated.
METHODS
Summary-level data from genome-wide association studies (GWAS) of Long COVID (N = 52615) and AIDs including inflammatory bowel disease (IBD) (N = 377277), Crohn's disease (CD) (N = 361508), ulcerative colitis (UC) (N = 376564), etc. were employed. Bidirectional causal effects were gauged between AIDs and Long COVID by exploiting Mendelian randomization (MR) and Bayesian model averaging (BMA).
RESULTS
The evidence of causal effects of IBD (OR = 1.06, 95% CI = 1.00-1.11, = 3.13E-02), CD (OR = 1.10, 95% CI = 1.01-1.19, = 2.21E-02) and UC (OR = 1.08, 95% CI = 1.03-1.13, = 2.35E-03) on Long COVID was found. In MR-BMA, UC was estimated as the highest-ranked causal factor (MIP = 0.488, MACE = 0.035), followed by IBD and CD.
CONCLUSION
This MR study found that IBD, CD and UC had causal effects on Long COVID, which suggests a necessity to screen high-risk populations.
背景
在感染新冠病毒后，有报告指出感染个体出现了新冠后遗症和自身免疫性疾病（AIDs）。然而，新冠后遗症和自身免疫性疾病之间可能有助于预防疾病的双向因果关系尚未得到充分研究。
方法
采用了来自新冠后遗症全基因组关联研究（GWAS）（N = 52615）以及自身免疫性疾病（包括炎症性肠病（IBD）（N = 377277）、克罗恩病（CD）（N = 361508）、溃疡性结肠炎（UC）（N = 376564）等）的汇总水平数据。通过孟德尔随机化（MR）和贝叶斯模型平均法（BMA）来评估自身免疫性疾病和新冠后遗症之间的双向因果关系。
结果
发现炎症性肠病（OR = 1.06，95%可信区间 = 1.00 - 1.11，P = 3.13E - 02）、克罗恩病（OR = 1.10，95%可信区间 = 1.01 - 1.19，P = 2.21E - 02）和溃疡性结肠炎（OR = 1.08，95%可信区间 = 1.03 - 1.13，P = 2.35E - 03）对新冠后遗症有因果效应。在MR - BMA中，溃疡性结肠炎被估计为排名最高的因果因素（最大后验包含概率（MIP） = 0.488，平均因果效应（MACE） = 0.035），其次是炎症性肠病和克罗恩病。
结论
这项孟德尔随机化研究发现，炎症性肠病、克罗恩病和溃疡性结肠炎对新冠后遗症有因果效应，这表明有必要筛查高危人群。
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