Jabeen Kokab, Bint Ali Sameen, Tufail Zainab, Mustafa Sana, Chaudhry Mahnoor, Tahir Muhammad J, Asghar Muhammad Sohaib, Ahmed Ali
Department of Pathology, Lahore General Hospital, Lahore, Pakistan.
Department of Pathology, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan.
Front Med (Lausanne). 2024 Jun 28;11:1363899. doi: 10.3389/fmed.2024.1363899. eCollection 2024.
, a gram-negative bacterium responsible for typhoid fever, can infect the inner lining or valves of the heart and cause endocarditis. This systematic review aimed to report cases of -associated endocarditis and its clinical features.
This systematic review was reported as per the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist. Only case reports and case series of endocarditis caused by , irrespective of age, gender, and demographics, were considered eligible for inclusion. To identify relevant studies, a literature search was conducted using relevant keywords on PubMed, Google Scholar, and the Cochrane Library from inception to 31 December 2023. After selecting the studies, the relevant data were extracted and pooled in terms of frequencies and percentages. A quality assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Case Reports.
This review included seven case reports, comprising 22.2% female and 77.8% male patients. The mean age of patients was 27.9 + 12.0 years. Regarding past medical history, 33.3% (3/9) of patients had a previous cardiac pathology. Fever remained the most common complaint, occurring in 88.9% of cases. Transthoracic and transesophageal echocardiography were used to diagnose all cases, with 33.3% identifying vegetation on the mitral, aortic, and tricuspid valves. Ceftriaxone, with or without gentamycin, remained the choice of antibiotic for 88.9% of cases, and all patients responded to the offered treatment.
-associated endocarditis, though rare, presents unique challenges and requires timely diagnosis. This systematic review of seven cases highlights a predominantly male population affected, with a mean age in the third decade, suggesting a higher invasiveness than other causes. The findings from this study underscore the importance of early recognition and appropriate management, primarily with antibiotic therapy. Further research with larger cohorts is crucial to refine understanding and guide policymaking for this rare but life-threatening condition.
伤寒杆菌是一种革兰氏阴性菌，可引发伤寒热，它能够感染心脏内膜或瓣膜并导致心内膜炎。本系统评价旨在报告伤寒杆菌相关性心内膜炎病例及其临床特征。
本系统评价按照系统评价与Meta分析的首选报告项目（PRISMA）清单进行报告。仅考虑由伤寒杆菌引起的心内膜炎的病例报告和病例系列，无论年龄、性别和人口统计学特征如何。为了识别相关研究，从创刊至2023年12月31日，在PubMed、谷歌学术和考克兰图书馆上使用相关关键词进行了文献检索。在选择研究后，提取相关数据并按频率和百分比进行汇总。使用乔安娜·布里格斯研究所病例报告关键评价清单进行质量评估。
本评价纳入了7篇病例报告，其中女性患者占22.2%，男性患者占77.8%。患者的平均年龄为27.9±12.0岁。关于既往病史，33.3%（3/9）的患者曾有心脏病变。发热仍然是最常见的主诉，88.9%的病例出现发热。所有病例均采用经胸和经食管超声心动图进行诊断，33.3%的病例在二尖瓣、主动脉瓣和三尖瓣上发现赘生物。88.9%的病例选择头孢曲松，联合或不联合庆大霉素，所有患者对所提供的治疗均有反应。
伤寒杆菌相关性心内膜炎虽然罕见，但存在独特挑战，需要及时诊断。对7例病例的本系统评价突出显示受影响的主要是男性人群，平均年龄在第三个十年，提示其侵袭性高于其他病因。本研究结果强调了早期识别和适当管理的重要性，主要是通过抗生素治疗。对更大队列进行进一步研究对于完善对这种罕见但危及生命疾病的认识并指导决策至关重要。
