Kida Izumi, Hayashi Naoki, Yokoyama Nozomu, Nagata Noriyuki, Sasaoka Kazuyoshi, Sasaki Noboru, Morishita Keitaro, Nakamura Kensuke, Kouguchi Hirokazu, Yagi Kinpei, Nakao Ryo, Takiguchi Mitsuyoshi, Nonaka Nariaki
Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Laboratory of Parasitology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Front Vet Sci. 2024 Jun 13;11:1373035. doi: 10.3389/fvets.2024.1373035. eCollection 2024.
is a cestode that causes human alveolar echinococcosis, a lethal zoonotic disease distributed in the northern hemisphere. The life cycle of this parasite is maintained in nature by voles as intermediate hosts and foxes as definitive hosts in Hokkaido, Japan. Although dogs are also susceptible to the parasite, the infection has been considered typically asymptomatic. We report the detection of eggs in the diarrheal feces of a dog with chronic gastrointestinal signs, which disappeared after anthelmintic treatment. The mitochondrial genome sequence constructed by sequencing of the overlapping PCRs using DNA from the eggs was identical to the most predominant haplotype previously reported in red foxes in Hokkaido. This case highlights that infection should be considered as a differential diagnosis for diarrheal dogs in the disease endemic areas. Further efforts are needed to accumulate parasite genotypes in domestic dogs as well as humans to assess the risk of human infection from dogs.
是一种绦虫,可导致人类肺泡型棘球蚴病,这是一种分布于北半球的致命人畜共患病。在日本北海道,这种寄生虫的生命周期在自然界中通过田鼠作为中间宿主和狐狸作为终宿主得以维持。虽然狗也易感染这种寄生虫,但感染通常被认为是无症状的。我们报告了在一只患有慢性胃肠道症状的狗的腹泻粪便中检测到虫卵,驱虫治疗后这些症状消失。使用来自虫卵的DNA通过重叠PCR测序构建的线粒体基因组序列与先前在北海道赤狐中报道的最主要单倍型相同。该病例突出表明,在疾病流行地区,对于腹泻的狗应考虑将这种感染作为鉴别诊断。需要进一步努力积累家犬以及人类中的寄生虫基因型,以评估狗传染给人类的风险。