急性和慢性白血病患者骨转换标志物的评估
Evaluation of Bone Turnover Markers in Patients with Acute and Chronic Leukemia.
作者信息
Al-Qaisi Reem A, Al-Gebori Abdulnasser M, Alosami Mohammed Hadi Munshed
机构信息
Department of Applied Sciences, Applied Chemists Division, University of Technology, Baghdad, Iraq.
Rheumatology Unit, Department of Medicine, Colleges of Medicine, University of Baghdad, Baghdad, Iraq.
出版信息
Indian J Clin Biochem. 2024 Jul;39(3):401-407. doi: 10.1007/s12291-023-01124-5. Epub 2023 Mar 3.
This study investigated different bone biomarkers (cross-linked carboxy-terminal telopeptide of type 1 collagen (CTX-1), pyridinoline (PYD), osteocalcin (OC), interleukin-6 receptor (IL-6R), calcium (Ca), and magnesium (Mg)) in terms of their metabolism in 4 different leukemia subtypes (ALL, AML, CLL and CML). The design was case control study with 30 controls and 60 cases of leukemia patients. Authors have reported many results regarding decrease as well as increase of specific bone biomarker under investigation with each leukemia subtype when compared to control. In addition, Authors reported correlations between each biomarker level and leukemia subtypes.
本研究调查了4种不同白血病亚型（急性淋巴细胞白血病、急性髓细胞白血病、慢性淋巴细胞白血病和慢性髓细胞白血病）中不同骨生物标志物（1型胶原交联羧基末端肽（CTX-1）、吡啶啉（PYD）、骨钙素（OC）、白细胞介素-6受体（IL-6R）、钙（Ca）和镁（Mg））的代谢情况。研究设计为病例对照研究，有30名对照者和60例白血病患者。作者报告了许多结果，即与对照组相比，每种白血病亚型所研究的特定骨生物标志物有降低也有升高。此外，作者还报告了每种生物标志物水平与白血病亚型之间的相关性。
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