Vassalle C, Sabatino L, Gaggini M, Mastorci F, Ndreu R, Minichilli Fabrizio, Del Turco S, Buzzigoli E, Pingitore A
Fondazione G. Monasterio CNR-Regione Toscana, Via G. Moruzzi 1, 56124, Pisa, Italy.
Institute of Clinical Physiology, National Research Council, Via G. Moruzzi 1, 56124, Pisa, Italy.
Eur J Appl Physiol. 2025 Jul 1. doi: 10.1007/s00421-025-05874-3.
Marathons and ultra-marathon generally evidence an anabolic effect on bone metabolism; however, there is scarce knowledge of less demanding events as half-marathons, which, instead, is becoming one of the most popular recreational activities, rising in the number of followers all over the world.
To evaluate the trend of bone turnover biomarkers (bone-specific alkaline phosphatase BALP, osteocalcin OC, type 1 procollagen amino-terminal peptide P1NP, bone formation biomarkers; and carboxy-terminal collagen crosslinks CTx, and bone reabsorption biomarker) and vitamin D (25(OH)D) in controls (CON) with a low physical activity profile and trained runners (ATH; at baseline, after a half-marathon run, and 24-h post), and their correlation with the systemic immune-inflammation index (SII) and other cardiometabolic parameters.
ATH showed higher levels of 25(OH)D and bone turnover biomarkers than CON; OC, BALP, P1NP, and CTx significantly increased after post-race (by 18, 20, 14, and 33%, respectively) as compared with baseline, and normalized at 24 h, except for P1NP which slowly decreased at 24 h; SII did not significantly change. In the whole population, all the bone turnover biomarkers were correlated with each other, 25(OH)D correlated with OC and BALP, whereas OC inversely correlated with diastolic blood pressure and 25(OH)D inversely correlated with body mass index. In the ATH group, no correlation between SII concentrations and levels of bone turnover biomarkers was found.
Both half-marathon training and acute responses after a running increase bone turnover biomarkers. More data are required to definitively assess if these changes are beneficial or adverse for bone health.
马拉松和超级马拉松通常对骨代谢具有合成代谢作用；然而，对于要求较低的赛事，如半程马拉松，人们了解甚少，而半程马拉松正成为最受欢迎的休闲活动之一，全球参与者数量不断增加。
评估身体活动水平较低的对照组（CON）和训练有素的跑步者（ATH；在基线、半程马拉松赛后及赛后24小时）的骨转换生物标志物（骨特异性碱性磷酸酶BALP、骨钙素OC、I型前胶原氨基末端肽P1NP，骨形成生物标志物；以及羧基末端胶原交联物CTx，骨吸收生物标志物）和维生素D（25(OH)D）的变化趋势，及其与全身免疫炎症指数（SII）和其他心血管代谢参数的相关性。
ATH的25(OH)D和骨转换生物标志物水平高于CON；与基线相比，赛后OC、BALP、P1NP和CTx显著升高（分别升高18%、20%、14%和33%），并在24小时恢复正常，但P1NP在24小时缓慢下降；SII无显著变化。在总体人群中，所有骨转换生物标志物相互关联，25(OH)D与OC和BALP相关，而OC与舒张压呈负相关，25(OH)D与体重指数呈负相关。在ATH组中，未发现SII浓度与骨转换生物标志物水平之间存在相关性。
半程马拉松训练和跑步后的急性反应均会增加骨转换生物标志物。需要更多数据来明确评估这些变化对骨骼健康是有益还是有害。
