Hartung Kaitlin M, Sletten Ellen M
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chem. 2023 Aug 10;9(8):2095-2109. doi: 10.1016/j.chempr.2023.05.016. Epub 2023 Jun 5.
As chemical biologists sought methods to modify and study biomolecules in their native environments, the need for bioorthogonal chemical reactions emerged. These fast and selective reactions between otherwise inert, abiotic functional groups have enabled exploration of some of the most intriguing and challenging questions in chemical biology. Further, the ability to perform organic reactions in cells and organisms has led to important applications in clinical spaces, and one reaction is now an integral part of a phase 2 trial for treating solid tumors. Given that bioorthogonal chemistry was a recipient of the 2022 Nobel Prize, we expect this field to be even more energized. Here, we highlight some of the most recent studies in this sphere and how these set the stage for where bioorthogonal chemistry is headed.
随着化学生物学家寻求在生物分子的天然环境中对其进行修饰和研究的方法，对生物正交化学反应的需求应运而生。这些发生在原本惰性的非生物官能团之间的快速且选择性的反应，使得人们能够探索化学生物学中一些最引人入胜且具有挑战性的问题。此外，在细胞和生物体中进行有机反应的能力已在临床领域产生了重要应用，目前有一种反应已成为治疗实体瘤的2期试验的一个组成部分。鉴于生物正交化学是2022年诺贝尔奖的获得者，我们预计该领域将更加活跃。在此，我们重点介绍该领域的一些最新研究，以及这些研究如何为生物正交化学的发展奠定基础。
