Mao Lixia, Liu Songtao, Chen Yongxia, Huang Huiyi, Ding Fenghua, Deng Liehua
Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Outpatient Appointment Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Front Cardiovasc Med. 2024 Jun 28;11:1399738. doi: 10.3389/fcvm.2024.1399738. eCollection 2024.
Septic cardiomyopathy, a life-threatening complication of sepsis, can cause acute heart failure and carry a high mortality risk. Current treatments have limitations. Fortunately, engineered exosomes, created through bioengineering technology, may represent a potential new treatment method. These exosomes can both diagnose and treat septic cardiomyopathy, playing a crucial role in its development and progression. This article examines the strategies for using engineered exosomes to protect cardiac function and treat septic cardiomyopathy. It covers three innovative aspects: exosome surface modification technology, the use of exosomes as a multifunctional drug delivery platform, and plant exosome-like nanoparticle carriers. The article highlights the ability of exosomes to deliver small molecules, proteins, and drugs, summarizing several RNA molecules, proteins, and drugs beneficial for treating septic cardiomyopathy. Although engineered exosomes are a promising biotherapeutic carrier, they face challenges in clinical application, such as understanding the interaction mechanism with host cells, distribution within the body, metabolism, and long-term safety. Further research is essential, but engineered exosomes hold promise as an effective treatment for septic cardiomyopathy.
脓毒症性心肌病是脓毒症的一种危及生命的并发症，可导致急性心力衰竭并伴有高死亡风险。目前的治疗方法存在局限性。幸运的是，通过生物工程技术制造的工程化外泌体可能代表一种潜在的新治疗方法。这些外泌体既能诊断又能治疗脓毒症性心肌病，在其发生和发展中起着关键作用。本文探讨了利用工程化外泌体保护心脏功能和治疗脓毒症性心肌病的策略。它涵盖了三个创新方面：外泌体表面修饰技术、将外泌体用作多功能药物递送平台以及植物外泌体样纳米颗粒载体。文章强调了外泌体递送小分子、蛋白质和药物的能力，总结了几种对治疗脓毒症性心肌病有益的RNA分子、蛋白质和药物。尽管工程化外泌体是一种有前途的生物治疗载体，但它们在临床应用中面临挑战，例如了解与宿主细胞的相互作用机制、在体内的分布、代谢以及长期安全性。进一步的研究至关重要，但工程化外泌体有望成为治疗脓毒症性心肌病的有效方法。
