Liu Sijia, Yang Ting, Jiang Qingsong, Zhang Liang, Shi Xinhui, Liu Xin, Li Xiaoli
Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China.
Key Laboratory for Biochemistry and Molecular Pharmacology of Chongqing, Chongqing, People's Republic of China.
J Inflamm Res. 2024 Jul 8;17:4405-4417. doi: 10.2147/JIR.S459185. eCollection 2024.
Sepsis is a disorder of the immune response to infection or infectious factors with high morbidity and mortality in clinical settings. The lactylation of lysine residues, fueled by lactate, plays a pivotal role in its pathophysiology. In conducting a literature review on sepsis-related research, we employed a systematic approach to ensure comprehensiveness and accuracy. Initially, we conducted an extensive literature search through the PubMed database, utilizing a range of keywords including "sepsis", "lactate", "lactylation", and "epigenetic modification". The aim was to capture the most recent research related to the pathophysiological mechanisms of sepsis, metabolic disorders, and the role of lactylation. The results of the literature review revealed a close link between sepsis and metabolic dysfunction, particularly the pivotal role of lactylation in regulating immune responses and inflammatory processes. Lactate, not only an energy metabolic byproduct produced during glycolysis, affects the activity of various proteins, including those involved in immune regulation and cell signaling, through lactylation. In the context of sepsis, changes in the levels of lactylation may be closely associated with the severity and prognosis of the disease. In summary, lactylation, as an emerging type of epigenetic modification, provides a new perspective for the diagnosis and treatment of sepsis. Future research needs to further elucidate the exact mechanisms of lactylation in sepsis and explore its potential as a therapeutic target.
脓毒症是一种针对感染或感染因素的免疫反应紊乱疾病，在临床环境中具有较高的发病率和死亡率。由乳酸驱动的赖氨酸残基乳酰化在其病理生理学中起关键作用。在对脓毒症相关研究进行文献综述时，我们采用了系统的方法以确保全面性和准确性。最初，我们通过PubMed数据库进行了广泛的文献检索，使用了一系列关键词，包括“脓毒症”、“乳酸”、“乳酰化”和“表观遗传修饰”。目的是获取与脓毒症病理生理机制、代谢紊乱以及乳酰化作用相关的最新研究。文献综述结果显示脓毒症与代谢功能障碍之间存在密切联系，尤其是乳酰化在调节免疫反应和炎症过程中的关键作用。乳酸不仅是糖酵解过程中产生的能量代谢副产物，还通过乳酰化影响各种蛋白质的活性，包括参与免疫调节和细胞信号传导的蛋白质。在脓毒症的背景下，乳酰化水平的变化可能与疾病的严重程度和预后密切相关。总之，乳酰化作为一种新兴的表观遗传修饰类型，为脓毒症的诊断和治疗提供了新的视角。未来的研究需要进一步阐明乳酰化在脓毒症中的具体机制，并探索其作为治疗靶点的潜力。
