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淀粉酶和脂肪酶正常的急性胰腺炎:诊断难题

Acute Pancreatitis With Normal Amylase and Lipase: A Diagnostic Dilemma.

作者信息

Ibrahim Hadiza, Jumani Adil, Elhassan Khalid, Ibrahim Mira, AlNajjar Majdi

机构信息

Internal Medicine, Zayed Military Hospital, Abu Dhabi, ARE.

Endocrinology, Zayed Military Hospital, Abu Dhabi, ARE.

出版信息

Cureus. 2024 Jun 14;16(6):e62374. doi: 10.7759/cureus.62374. eCollection 2024 Jun.

DOI:10.7759/cureus.62374
PMID:39006609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246614/
Abstract

Acute pancreatitis is a common and potentially life-threatening condition. It is characterized by inflammation of the pancreas, most often leading to elevated levels of pancreatic enzymes in the blood. In a subset of patients, however, conventional biomarker levels may remain within the reference range. Such instances have the potential to create a diagnostic challenge for healthcare professionals and can lead to misdiagnosis or delayed treatment. This article presents the intriguing clinical scenario of acute pancreatitis with normal amylase and lipase, discusses factors that may lead to normoenzymatic presentation, and reminds clinicians of the diagnostic criteria for acute pancreatitis, which does not necessarily require elevated pancreatic enzymes.

摘要

急性胰腺炎是一种常见且可能危及生命的疾病。其特征为胰腺炎症,多数情况下会导致血液中胰腺酶水平升高。然而,在一部分患者中,传统生物标志物水平可能仍处于参考范围内。这种情况有可能给医护人员带来诊断挑战,并可能导致误诊或治疗延误。本文介绍了淀粉酶和脂肪酶正常的急性胰腺炎这一有趣的临床情况,讨论了可能导致酶水平正常表现的因素,并提醒临床医生注意急性胰腺炎的诊断标准,该标准不一定要求胰腺酶升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa5/11246614/8bf5492d1355/cureus-0016-00000062374-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa5/11246614/8993fa6ea405/cureus-0016-00000062374-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa5/11246614/ad8a4ced89da/cureus-0016-00000062374-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa5/11246614/8bf5492d1355/cureus-0016-00000062374-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa5/11246614/8993fa6ea405/cureus-0016-00000062374-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa5/11246614/ad8a4ced89da/cureus-0016-00000062374-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa5/11246614/8bf5492d1355/cureus-0016-00000062374-i03.jpg

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Dipeptidyl peptidase-4 inhibitors, pancreatic cancer and acute pancreatitis: A meta-analysis with trial sequential analysis.二肽基肽酶-4 抑制剂、胰腺癌和急性胰腺炎:一项荟萃分析与试验序贯分析。
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