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揭示甲硝唑的神经毒性：一个临床难题。

Unveiling the Neurotoxicity of Metronidazole: A Clinical Conundrum.

作者信息

Hithesh Gollapudi, Moorthy Swathy, M Lakshmi, Bhaskar Emmanuel

机构信息

General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.

Internal Medicine, Sri Ramachandra Medical College, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.

出版信息

Cureus. 2024 Jun 12;16(6):e62219. doi: 10.7759/cureus.62219. eCollection 2024 Jun.

DOI:10.7759/cureus.62219
PMID:39006673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240243/
Abstract

Metronidazole, a commonly used antiprotozoal agent, has been linked to neurotoxicity in a few individuals. We present the case of a 61-year-old gentleman diagnosed with a liver abscess, who received a total dose of 64 g of metronidazole over a four-week duration. He subsequently developed slurred speech, numbness, and tingling sensation in both feet. His neuroimaging revealed T2 hyperintensities in the bilateral dentate nuclei and withdrawal of the drug led to symptomatic improvement in the patient. Metronidazole is known to produce neurological manifestations with involvement of peripheral nerves and cerebellum commonly. In the present case, the cumulative dose impact of metronidazole on the dentate nucleus was evident.

摘要

甲硝唑是一种常用的抗原虫药物，在少数个体中与神经毒性有关。我们报告一例61岁男性，诊断为肝脓肿，在四周内共接受了64克甲硝唑治疗。随后，他出现了言语不清、双脚麻木和刺痛感。他的神经影像学检查显示双侧齿状核T2高信号，停用该药物后患者症状有所改善。已知甲硝唑通常会引起累及周围神经和小脑的神经学表现。在本病例中，甲硝唑对齿状核的累积剂量影响明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/5ba1b263b927/cureus-0016-00000062219-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/163f497fce8a/cureus-0016-00000062219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/bd4618c99702/cureus-0016-00000062219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/6aec2a20c11f/cureus-0016-00000062219-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/5ba1b263b927/cureus-0016-00000062219-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/163f497fce8a/cureus-0016-00000062219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/bd4618c99702/cureus-0016-00000062219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/6aec2a20c11f/cureus-0016-00000062219-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b96c/11240243/5ba1b263b927/cureus-0016-00000062219-i04.jpg

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本文引用的文献

1
Efficacy of empirical Ciprofloxacin or Cefixime plus Metronidazole therapy for the treatment of liver abscess: a randomized control clinical trial.经验性环丙沙星或头孢克肟联合甲硝唑治疗肝脓肿的疗效：一项随机对照临床试验。
Sci Rep. 2024 May 20;14(1):11430. doi: 10.1038/s41598-024-59607-1.
2
Metronidazole-associated Neurologic Events: A Nested Case-control Study.甲硝唑相关神经系统事件：一项巢式病例对照研究。
Clin Infect Dis. 2021 Jun 15;72(12):2095-2100. doi: 10.1093/cid/ciaa395.
3
Clinical relevance of metronidazole and peripheral neuropathy: a systematic review of the literature.
甲硝唑与周围神经病变的临床相关性：文献系统评价。
Int J Antimicrob Agents. 2018 Mar;51(3):319-325. doi: 10.1016/j.ijantimicag.2017.08.033. Epub 2017 Sep 5.
4
Metronidazole-induced encephalopathy in a patient with Crohn's disease.一名克罗恩病患者的甲硝唑诱发的脑病
Intest Res. 2017 Jan;15(1):124-129. doi: 10.5217/ir.2017.15.1.124. Epub 2017 Jan 31.
5
Metronidazole-Induced Cerebellar Toxicity.甲硝唑诱发的小脑毒性。
Neurol Int. 2016 Apr 1;8(1):6365. doi: 10.4081/ni.2016.6365.
6
Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy.低分化肝细胞癌伴抗Hu抗体阳性副肿瘤性周围神经病。
Pathol Int. 2015 Jul;65(7):388-92. doi: 10.1111/pin.12304. Epub 2015 May 4.
7
Neurologic complications of metronidazole.甲硝唑的神经并发症
Can J Neurol Sci. 2013 Nov;40(6):768-76. doi: 10.1017/s0317167100015870.
8
Metronidazole-induced central nervous system toxicity: a systematic review.甲硝唑诱发的中枢神经系统毒性：一项系统评价
Clin Neuropharmacol. 2011 Nov-Dec;34(6):241-7. doi: 10.1097/WNF.0b013e3182334b35.
9
Generation of nitro radical anions of some 5-nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neurotoxicity caused by nitroheterocyclic drugs.去甲肾上腺素、多巴胺和血清素对一些5-硝基呋喃、2-硝基咪唑和5-硝基咪唑的硝基自由基阴离子的生成作用。硝基杂环药物引起神经毒性的一种可能机制。
J Biol Chem. 1987 Aug 25;262(24):11731-6.
10
Enzymatic conversion of the antibiotic metronidazole to an analog of thiamine.
Arch Biochem Biophys. 1987 Sep;257(2):357-62. doi: 10.1016/0003-9861(87)90577-7.