Pálešová Nina, Řiháčková Katarína, Kuta Jan, Pindur Aleš, Šebejová Ludmila, Čupr Pavel
RECETOX, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
Faculty of Sports Studies, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
Environ Sci Technol Lett. 2024 Jun 12;11(7):679-686. doi: 10.1021/acs.estlett.4c00272. eCollection 2024 Jul 9.
Increased wildfire activity increases the demands on fire rescue services and firefighters' contact with harmful chemicals. This study aimed to determine firefighters' exposure to toxic metal(loid)s and its association with the lipid profile. CELSPAC-FIREexpo study participants (including 110 firefighters) provided urine and blood samples to quantify urinary levels of metal(loid)s (arsenic, cadmium (Cd), mercury, and lead (Pb)), and serum lipid biomarkers (cholesterol (CHOL), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides (TG)). The associations were investigated by using multiple linear regression and Bayesian weighted quantile sum (BWQS) regression. Higher levels of Pb were observed in firefighters. Pb was positively associated with CHOL and TG. Cd was negatively associated with HDL. In the BWQS model, the mixture of metal(loid)s was associated positively with CHOL (β = 14.75, 95% CrI = 2.45-29.08), LDL (β = 15.14, 95% CrI = 3.39-29.35), and TG (β = 14.79, 95% CrI = 0.73-30.42), while negatively with HDL (β = -14.96, 95% CrI = -25.78 to -1.8). Pb emerged as a key component in a metal(loid) mixture. The results suggest that higher exposure to lead and the mixture of metal(loid)s is associated with the alteration of the lipid profile, which can result in an unfavorable cardiometabolic profile, especially in occupationally exposed firefighters.
野火活动增加对消防救援服务的需求，也增加了消防员与有害化学物质的接触。本研究旨在确定消防员对有毒金属（类金属）的暴露情况及其与血脂谱的关联。CELSPAC - FIREexpo研究参与者（包括110名消防员）提供了尿液和血液样本，以量化尿液中金属（类金属）（砷、镉（Cd）、汞和铅（Pb））的水平以及血清脂质生物标志物（胆固醇（CHOL）、低密度脂蛋白胆固醇（LDL）、高密度脂蛋白胆固醇（HDL）和甘油三酯（TG））。通过多元线性回归和贝叶斯加权分位数和（BWQS）回归研究这些关联。在消防员中观察到较高的铅水平。铅与CHOL和TG呈正相关。镉与HDL呈负相关。在BWQS模型中，金属（类金属）混合物与CHOL（β = 14.75，95% CrI = 2.45 - 29.08）、LDL（β = 15.14，95% CrI = 3.39 - 29.35）和TG（β = 14.79，95% CrI = 0.73 - 30.42）呈正相关，而与HDL呈负相关（β = -14.96，95% CrI = -25.78至-1.8）。铅成为金属（类金属）混合物中的关键成分。结果表明，较高的铅暴露和金属（类金属）混合物与血脂谱的改变有关，这可能导致不良的心脏代谢状况，尤其是在职业暴露的消防员中。
