Bernabeu C, Maziarz R, Murre C, Terhorst C
Mol Immunol. 1985 Aug;22(8):955-60. doi: 10.1016/0161-5890(85)90082-3.
Bovine beta 2-microglobulin (beta 2-m) present in fetal calf serum (FCS) is able to replace endogenous beta 2-m associated with several class I antigens from human and mouse cells maintained in culture [Bernabeu et al. (1984) Nature, Lond. 308, 642-645]. Here we show that human HLA-A2 and HLA-B7, as well as mouse H-2Ld and H-2Dd heavy chains expressed after gene transfer in mouse L-cells, associate to a large extent with bovine beta 2-m. We also demonstrate that bovine beta 2-m associated with the endogenous H-2Kk/Dk heavy chains generates an antibody response when L-cells are injected into syngeneic C3H mice.
胎牛血清（FCS）中存在的牛β2-微球蛋白（β2-m）能够替代与培养中的人源和鼠源细胞的几种I类抗原相关的内源性β2-m [贝纳贝乌等人（1984年），《自然》，伦敦，第308卷，642 - 645页]。在此我们表明，基因转移至小鼠L细胞后表达的人HLA - A2和HLA - B7，以及小鼠H - 2Ld和H - 2Dd重链，在很大程度上与牛β2-m相关联。我们还证明，当将L细胞注射到同基因的C3H小鼠体内时，与内源性H - 2Kk / Dk重链相关联的牛β2-m会引发抗体反应。
