2型糖尿病患者糖化白蛋白与糖化血红蛋白A1c比值与季节变化及COVID-19大流行的关联
Association of the Ratio of Glycoalbumin to Hemoglobin A1c With Season Change and the COVID-19 Pandemic in Patients With Type 2 Diabetes Mellitus.
作者信息
Takebayashi Kohzo, Yamauchi Mototaka, Hara Kenji, Tsuchiya Takafumi, Hashimoto Koshi
机构信息
Department of Diabetes, Endocrinology and Hematology, Dokkyo Medical University Saitama Medical Center, Koshigaya, JPN.
出版信息
Cureus. 2024 Jul 13;16(7):e64444. doi: 10.7759/cureus.64444. eCollection 2024 Jul.
AIM
The main purpose of the current study was to investigate the effect of season change and the influence of the COVID-19 pandemic on the ratio of glycoalbumin to hemoglobin A1c (GA/HbA1c) in patients with type 2 diabetes.
PATIENTS AND METHODS
A total of 267 patients in whom both HbA1c and GA were measured at baseline were included in this retrospective study. GA/HbA1c was investigated for three years, 2018, 2019, and 2020 (COVID-19 pandemic period).
RESULTS
The mean values for GA/HbA1c per year in 2018, 2019, and 2020 were 2.64±0.35, 2.61±0.35, 2.64±0.39, respectively. There were no significant differences in GA/HbA1c during these years. There was a tendency toward seasonal variation in GA/HbA1c (i.e., higher in summer or autumn and lower in spring or winter).
CONCLUSION
In patients with type 2 diabetes, GA/HbA1c tended to show seasonal variation, which was not influenced by the COVID-19 pandemic.
目的
本研究的主要目的是调查季节变化以及2019冠状病毒病大流行对2型糖尿病患者糖化白蛋白与糖化血红蛋白A1c比值（GA/HbA1c）的影响。
患者与方法
本回顾性研究纳入了267例在基线时同时测量了HbA1c和GA的患者。对2018年、2019年和2020年（2019冠状病毒病大流行期间）这三年的GA/HbA1c进行了调查。
结果
2018年、2019年和2020年每年GA/HbA1c的平均值分别为2.64±0.35、2.61±0.35、2.64±0.39。这些年份的GA/HbA1c无显著差异。GA/HbA1c存在季节性变化趋势（即夏季或秋季较高，春季或冬季较低）。
结论
在2型糖尿病患者中，GA/HbA1c往往呈现季节性变化，且不受2019冠状病毒病大流行的影响。
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