使用糖化白蛋白/糖化血红蛋白比值改善1型糖尿病患者高血糖状态的监测

Improved Monitoring of the Hyperglycemic State in Type 1 Diabetes Patients by Use of the Glycoalbumin/HbA1c Ratio.

作者信息

Imai Takatoshi, Oikawa Yoichi, Shimada Akira

机构信息

Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

出版信息

Rev Diabet Stud. 2007 Spring;4(1):44-8. doi: 10.1900/RDS.2007.4.44. Epub 2007 May 10.

DOI:10.1900/RDS.2007.4.44

PMID:17565415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1892520/

Abstract

AIM

Generally, the level of glycoalbumin (GA) is approximately 3 times higher than that of HbA1c. However, in type 1 diabetic patients, we often find an even higher GA/HbA1c ratio of nearly 3.5. Therefore, this study was performed to examine the significance of a higher GA/HbA1c ratio.

METHODS

17 type 1 diabetic patients were enrolled in part 1 of the study and divided into two groups, one with a higher and the other with a lower GA/HbA1c ratio. In both groups, the correlation between GA or HbA1c level and each "4-point" capillary glucose level was analyzed. 80 type 1 diabetic patients were enrolled in part 2 of the study and the relationship between mean GA/HbA1c ratio in the past year and degree of diabetic retinopathy was analyzed.

RESULTS

In part 1 of the study, we found positive correlations between GA and bedtime capillary glucose levels and between HbA1c and bedtime capillary glucose levels in the higher GA/HbA1c group (r = 0.86, p = 0.023; r = 0.95, p = 0.012, respectively), but not in the lower GA/HbA1c group. In part 2 of the study, a significant positive correlation between GA/HbA1c ratio and severity of retinopathy could be observed (r = 0.269, p = 0.017).

CONCLUSIONS

A higher GA/HbA1c ratio may reflect a postprandial hyperglycemic state and simultaneous monitoring of GA and HbA1c may improve the management of diabetic patients.

摘要

目的

一般来说，糖化白蛋白（GA）水平约为糖化血红蛋白（HbA1c）水平的3倍。然而，在1型糖尿病患者中，我们经常发现GA/HbA1c比值甚至更高，接近3.5。因此，本研究旨在探讨较高GA/HbA1c比值的意义。

方法

17名1型糖尿病患者纳入研究的第1部分，并分为两组，一组GA/HbA1c比值较高，另一组较低。在两组中，分析GA或HbA1c水平与每个“4点”毛细血管血糖水平之间的相关性。80名1型糖尿病患者纳入研究的第2部分，分析过去一年的平均GA/HbA1c比值与糖尿病视网膜病变程度之间的关系。

结果

在研究的第1部分中，我们发现较高GA/HbA1c组中GA与睡前毛细血管血糖水平之间以及HbA1c与睡前毛细血管血糖水平之间存在正相关（r = 0.86，p = 0.023；r = 0.95，p = 0.012），但在较低GA/HbA1c组中未发现。在研究的第2部分中，可以观察到GA/HbA1c比值与视网膜病变严重程度之间存在显著正相关（r = 0.269，p = 0.017）。