Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.
Oral Dis. 2024 Oct;30(7):4145-4151. doi: 10.1111/odi.15043. Epub 2024 Jul 15.
The palatal mucosa exhibits a notable ability to regenerate without causing scarring during the process of wound healing, rendering it a highly valuable reservoir of mesenchymal stem cells (MSCs). The aim of this review is to summarize the different sources of MSCs derived from hard palatal (PMSCs), thereby presenting a promising avenue for the utilization of regenerative medicine.
Pertinent literatures focused on the sources, identification methods, and advantageous characteristics of PMSCs are obtained from PubMed and Web of Science.
PMSCs, originating from the hard palate periosteum, subepithelial adipose tissue, and lamina propria, have been successfully isolated and characterized, with positive markers for MSCs and negative markers for hematopoietic stem cells. Moreover, PMSCs demonstrate resistance to inflammatory stimuli, enabling uninterrupted osteogenesis in the presence of inflammation. Additionally, PMSCs possess a notable migratory capacity, facilitating prompt arrival at the site of injury. Furthermore, PMSCs exhibit various advantageous inherent in stem cells, including clonogenicity, self-renewal capability, and pluripotent differentiation potential.
PMSCs have stem cell-related properties and can be used for regenerative medicine of cells and tissues in the future.
腭黏膜在创伤愈合过程中具有显著的再生能力而不产生瘢痕，使其成为间充质干细胞（MSCs）的重要来源。本综述旨在总结硬腭（PMSCs）来源的 MSCs 的不同来源，从而为再生医学的应用提供一个有前途的途径。
从 PubMed 和 Web of Science 中获取了关于 PMSCs 的来源、鉴定方法和有利特征的相关文献。
PMSCs 来源于硬腭骨膜、黏膜下脂肪组织和固有层，已成功分离和鉴定，其 MSC 标志物阳性，造血干细胞标志物阴性。此外，PMSCs 对炎症刺激具有抗性，能够在炎症存在的情况下不间断地进行成骨作用。此外，PMSCs 具有显著的迁移能力，能够迅速到达损伤部位。此外，PMSCs 具有各种与干细胞相关的固有优势，包括克隆形成能力、自我更新能力和多能分化潜能。
PMSCs 具有干细胞相关特性，可用于未来的细胞和组织再生医学。
