Feng Yunfei, Morato Nicolás M, Huang Kai-Hung, Lin Mina, Cooks R Graham
Department of Chemistry, Bindley Bioscience Center, and Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Chem Commun (Camb). 2024 Aug 1;60(63):8224-8227. doi: 10.1039/d4cc02346c.
The current opioid epidemic has incentivized the discovery of new non-addictive analgesics, a process that requires the screening of opioid receptor binding, traditionally performed using radiometric assays. Here we describe a label-free alternative based on high-throughput (1 Hz) ambient mass spectrometry for screening the receptor binding of new opioid analogues.
当前的阿片类药物流行促使人们去发现新的非成瘾性镇痛药，这一过程需要筛选阿片受体结合情况，传统上是使用放射性测定法来进行的。在此，我们描述了一种基于高通量（1赫兹）常压质谱的无标记替代方法，用于筛选新型阿片类类似物的受体结合情况。
