Trapping of particles diffusing in cylindrical cavity of arbitrary length and radius by two small absorbing disks on the cavity side wall: Narrow escape theory and beyond.

Narrow escape theory deals with the first passage of a particle diffusing in a cavity with small circular windows on the cavity wall to one of the windows. Assuming that (i) the cavity has no size anisotropy and (ii) all windows are sufficiently far away from each other, the theory provides an analytical expression for the particle mean first-passage time (MFPT) to one of the windows. This expression shows that the MFPT depends on the only global parameter of the cavity, its volume, independent of the cavity shape, and is inversely proportional to the product of the particle diffusivity and the sum of the window radii. Amazing simplicity and universality of this result raises the question of the range of its applicability. To shed some light on this issue, we study the narrow escape problem in a cylindrical cavity of arbitrary size anisotropy with two small windows arbitrarily located on the cavity side wall. We derive an approximate analytical solution for the MFPT, which smoothly goes from the conventional narrow escape solution in an isotropic cavity when the windows are sufficiently far away from each other to a qualitatively different solution in a long cylindrical cavity (the cavity length significantly exceeds its radius). Our solution demonstrates the mutual influence of the windows on the MFPT and shows how it depends on the inter-window distance. A key step in finding the solution is an approximate replacement of the initial three-dimensional problem by an equivalent one-dimensional one, where the particle diffuses along the cavity axis and the small absorbing windows are modeled by delta-function sinks. Brownian dynamics simulations are used to establish the range of applicability of our approximate approach and to learn what it means that the two windows are far away from each other.