心房颤动和高龄可预测心力衰竭患者血清脑源性神经营养因子水平。
Atrial Fibrillation and Older Age Predict Serum Brain-Derived Neurotrophic Factor Levels Among Patients With Heart Failure.
作者信息
Pressler Susan J, Jung Miyeon, Dorsey Susan G, Giordani Bruno, Titler Marita G, Wierenga Kelly L, Clark David G, Smith Dean G, Smith Asa B, Gradus-Pizlo Irmina, Pressler Milton L
出版信息
J Cardiovasc Nurs. 2024 Jul 10. doi: 10.1097/JCN.0000000000001110.
BACKGROUND
Predictors have not been determined of serum brain-derived neurotrophic factor (BDNF) levels among patients with heart failure (HF).
OBJECTIVE
The primary purpose was to evaluate history of atrial fibrillation, age, gender, and left ventricular ejection fraction as predictors of serum BDNF levels at baseline, 10 weeks, and 4 and 8 months after baseline among patients with HF.
METHODS
This study was a retrospective cohort analyses of 241 patients with HF. Data were retrieved from the patients' health records (coded history of atrial fibrillation, left ventricular ejection fraction), self-report (age, gender), and serum BDNF. Linear multiple regression analyses were conducted.
RESULTS
One hundred three patients (42.7%) had a history of atrial fibrillation. History of atrial fibrillation was a significant predictor of serum BDNF levels at baseline (β = -0.16, P = .016), 4 months (β = -0.21, P = .005), and 8 months (β = -0.19, P = .015). Older age was a significant predictor at 10 weeks (β = -0.17, P = .017) and 4 months (β = -0.15, P = .046).
CONCLUSIONS
Prospective studies are needed to validate these results. Clinicians need to assess patients with HF for atrial fibrillation and include treatment of it in management plans.
背景
心力衰竭（HF）患者血清脑源性神经营养因子（BDNF）水平的预测因素尚未确定。
目的
主要目的是评估心房颤动病史、年龄、性别和左心室射血分数作为HF患者基线、10周以及基线后4个月和8个月时血清BDNF水平的预测因素。
方法
本研究是对241例HF患者进行的回顾性队列分析。数据取自患者的健康记录（心房颤动编码病史、左心室射血分数）、自我报告（年龄、性别）以及血清BDNF。进行线性多元回归分析。
结果
103例患者（42.7%）有心房颤动病史。心房颤动病史是基线时（β = -0.16，P = .016）、4个月时（β = -0.21，P = .005）和8个月时（β = -0.19，P = .015）血清BDNF水平的显著预测因素。年龄较大是10周时（β = -0.17，P = .017）和4个月时（β = -0.15，P = .046）的显著预测因素。
结论
需要进行前瞻性研究以验证这些结果。临床医生需要评估HF患者是否存在心房颤动，并将其治疗纳入管理计划。
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