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通过双向束跟踪同步辐射装置对软组织进行高角度灵敏度 X 射线相衬显微断层成像。

High-angular-sensitivity X-ray phase-contrast microtomography of soft tissue through a two-directional beam-tracking synchrotron set-up.

机构信息

Department of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom.

Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, United Kingdom.

出版信息

J Synchrotron Radiat. 2024 Sep 1;31(Pt 5):1293-1298. doi: 10.1107/S1600577524005034. Epub 2024 Jul 15.

DOI:10.1107/S1600577524005034
PMID:39007822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11371031/
Abstract

Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into an array of independent circular beamlets that are resolved by a high-resolution detector. It features isotropic spatial resolution, provides two-dimensional phase sensitivity, and enables the three-dimensional reconstructions of the refractive index decrement, δ, and the attenuation coefficient, μ. In this work, the angular sensitivity and the spatial resolution of 2DBT images in a synchrotron-based implementation is reported. In its best configuration, angular sensitivities of ∼20 nrad and spatial resolution of at least 6.25 µm in phase-contrast images were obtained. Exemplar application to the three-dimensional imaging of soft tissue samples, including a mouse liver and a decellularized porcine dermis, is also demonstrated.

摘要

双向光束跟踪（2DBT）是一种用于相衬成像和层析成像的方法，它使用强度调制器将 X 射线光束构造为一组独立的圆形射束，这些射束由高分辨率探测器分辨。它具有各向同性的空间分辨率，提供二维相位灵敏度，并能够对折射率差 δ 和衰减系数 μ 进行三维重建。在这项工作中，报道了基于同步加速器的 2DBT 图像的角度灵敏度和空间分辨率。在最佳配置下，在相衬图像中获得了约 20nrad 的角度灵敏度和至少 6.25μm 的空间分辨率。还展示了对软组织样本的三维成像的示例应用，包括小鼠肝脏和去细胞化的猪皮。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/55cd6a1830ab/s-31-01293-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/67cd6c5142d0/s-31-01293-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/f48ebc1f77c1/s-31-01293-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/17fc8130fa4a/s-31-01293-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/55cd6a1830ab/s-31-01293-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/67cd6c5142d0/s-31-01293-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/f48ebc1f77c1/s-31-01293-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/17fc8130fa4a/s-31-01293-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cf4/11371031/55cd6a1830ab/s-31-01293-fig4.jpg

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