V. N. KARAZIN KHARKIV NATIONAL UNIVERSITY, KHARKIV, UKRAINE.
COMENIUS UNIVERSITY, BRATISLAVA, SLOVAKIA.
Wiad Lek. 2024;77(5):1086-1092. doi: 10.36740/WLek202405132.
Aim: The study of the role of micronutrients in the prevention of the severe course of the coronavirus disease.
Materials and Methods: In order to fulfill the task, there was conducted an analytical review of medical and biological publications in English in the electronic databases PubMed Medline of the US National Library of Medicine (NLM), Embase, Cochrane Database of Systematic Reviews for the period from 2015 to November 2023, where included 50 published articles, 28 preprints and 109 trials. In the course of the study, the bibliographic-semantic research method was used according to the "Preferred Reporting Elements for Systematic Reviews and Meta-Analyses" (PRISMA) protocol. According to this protocol, identified literary sources were sequentially analyzed by title, keywords, abstract and full text of articles. Based on the results of 16 searches, 2650 articles from PubMed, Cochrane Database of Systematic Reviews and Embase, 3162 articles from preprint servers and 237 trials were rejected. In the final article synthesis, we included 50 published articles, 28 preprints, and 109 trials.
Conclusions: The most effective in preventing complications of the coronavirus disease are vitamins A, D, E, K, C, B3, B6, B9, B12 and such mineral substances as Mg, Se and Zn. The consumption of appropriate bioactive complexes and source products can be considered a clinically and economically effective strategy for the prevention of a severe course of the coronavirus disease.
目的：研究微量营养素在预防冠状病毒病严重病程中的作用。
材料和方法：为了完成任务，对美国国家医学图书馆（NLM）的 PubMed Medline、Embase 和 Cochrane 系统评价数据库中的英文医学和生物学出版物进行了分析性综述，检索时间从 2015 年到 2023 年 11 月，共纳入 50 篇已发表文章、28 篇预印本和 109 项试验。在研究过程中，根据“系统评价和荟萃分析的首选报告元素”（PRISMA）方案使用了文献语义研究方法。根据该方案，对标题、关键词、摘要和文章全文进行了顺序分析，对已识别的文献来源进行了分析。根据 16 次搜索的结果，从 PubMed、Cochrane 系统评价数据库和 Embase 中排除了 2650 篇文章，从预印本服务器中排除了 3162 篇文章，从试验中排除了 237 篇文章。在最终的文章综合中，我们纳入了 50 篇已发表的文章、28 篇预印本和 109 项试验。
结论：预防冠状病毒病并发症最有效的是维生素 A、D、E、K、C、B3、B6、B9、B12 和矿物质镁、硒和锌。适当的生物活性复合物和来源产品的消费可以被认为是预防冠状病毒病严重病程的一种具有临床和经济效益的策略。
