Rahman Parbin, Chakraborty Nikita, Patel Bhisma K, Rajbongshi Kamal K
Department of Chemistry, Handique Girls' College, Guwahati 781001, Assam, India.
Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati 781039, India.
J Org Chem. 2024 Aug 2;89(15):10472-10484. doi: 10.1021/acs.joc.4c00585. Epub 2024 Jul 15.
An iodine-promoted C═C bond cleavage with concomitant decarboxylation and cross-coupling between cinnamic acids and -sulfoximines has been developed. This reaction proceeds via selective C═C bond cleavage, followed by decarboxylation and oxidative sulfoximidation. This metal- and base-free protocol involves dioxygen as the source of oxygen, which is facilitated by -butyl hydroperoxide (TBHP) as the oxidant affording -aroylated sulfoximines with good functional group tolerance and good yields.
已开发出一种碘促进的碳碳双键断裂反应，该反应伴随着肉桂酸与亚砜亚胺之间的脱羧和交叉偶联。此反应通过选择性碳碳双键断裂进行，随后是脱羧和氧化亚砜化。这种无金属和无碱的反应体系以氧气作为氧源，由叔丁基过氧化氢（TBHP）作为氧化剂促进反应，可得到具有良好官能团耐受性和高产率的α-芳酰化亚砜亚胺。
