State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Department of Educational Science, Hunan First Normal University, Changsha 410205, China.
Org Lett. 2020 Apr 3;22(7):2522-2526. doi: 10.1021/acs.orglett.0c00271. Epub 2020 Mar 24.
A selective functionalization of C-C═C bonds toward N-C═O bonds is realized by an -BuNI-catalyzed reaction of 3-methylindoles with primary amines using TBHP as the unique oxidant. The systematic process involves oxygenation, nitrogenation, ring-opening, and recyclization, affording a broad range of quinazolinones in good to excellent yields.
通过 -BuNI 催化 3-甲基吲哚与伯胺在 TBHP 作为唯一氧化剂的反应，实现了 C-C═C 键到 N-C═O 键的选择性功能化。该系统过程涉及氧化、氮化、开环和再循环，以良好至优异的收率得到了广泛的喹唑啉酮。
