Department of Chemistry, Gachon University, Seongnam, 13120, South Korea.
Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, 580 031, India; Korea University, Seoul, South Korea; School of Engineering, University of Petroleum and Energy Studies (UPES) Uttarakhand, Dehradun, 248 007, India.
J Environ Manage. 2024 Aug;366:121727. doi: 10.1016/j.jenvman.2024.121727. Epub 2024 Jul 14.
Determining hazardous substances in the environment is vital to maintaining the safety and health of all components of society, including the ecosystem and humans. Recently, protein-based nanobiosensors have emerged as effective tools for monitoring potentially hazardous substances in situ. Nanobiosensor detection mode is a combination of particular plasmonic nanomaterials (e.g., nanoparticles, nanotubes, quantum dots, etc.), and specific bioreceptors (e.g., aptamers, antibodies, DNA, etc.), which has the benefits of high selectivity, sensitivity, and compatibility with biological systems. The role of these nanobiosensors in identifying dangerous substances (e.g., heavy metals, organic pollutants, pathogens, toxins, etc.) is discussed along with different detection mechanisms and various transduction methods (e.g., electrical, optical, mechanical, electrochemical, etc.). In addition, topics discussed include the design and construction of these sensors, the selection of proteins, the integration of nanoparticles, and their development processes. A discussion of the challenges and prospects of this technology is also included. As a result, protein nanobiosensors are introduced as a powerful tool for monitoring and improving environmental quality and community safety.
确定环境中的有害物质对于维护社会各组成部分（包括生态系统和人类）的安全和健康至关重要。最近，基于蛋白质的纳米生物传感器已成为原位监测潜在有害物质的有效工具。纳米生物传感器检测模式是特定等离子体纳米材料（例如纳米粒子、纳米管、量子点等）与特定生物受体（例如适体、抗体、DNA 等）的结合，具有高选择性、灵敏度和与生物系统兼容性的优点。本文讨论了这些纳米生物传感器在识别危险物质（例如重金属、有机污染物、病原体、毒素等）方面的作用，以及不同的检测机制和各种转换方法（例如电、光、机械、电化学等）。此外，还讨论了这些传感器的设计和构建、蛋白质的选择、纳米粒子的集成及其开发过程。本文还讨论了该技术的挑战和前景。因此，蛋白质纳米生物传感器被引入作为监测和改善环境质量和社区安全的有力工具。
