Department of Orthopaedics, The 960th Hospital of PLA, Jinan 250031, China.
Department of Orthopaedics, The 960th Hospital of PLA, Jinan 250031, China; The Second Medical University of Shandong, Weifang, Shandong 261000, China.
Int Immunopharmacol. 2024 Sep 30;139:112684. doi: 10.1016/j.intimp.2024.112684. Epub 2024 Jul 14.
The human immune system is capable of defending against, monitoring, and self-stabilizing various immune cells. Differentiation, proliferation, and development of these cells are regulated by biochemical signals. Moreover, biophysical signals, such as mechanical forces, have been found to affect immune cell function, thus introducing a new area of immunological research. Piezo1, a mechanically sensitive ion channel, was awarded the Nobel Prize for Physiology and Medicine in 2021. This channel is present on the surface of many cells, and when stimulated by mechanical force, it controls calcium (Ca) inside the cells, leading to changes in downstream signals and thus regulating cell functions. Piezo1 is also expressed in various innate and adaptive immune cells and plays a major role in the immune function. In this review, we will explore the physiological functions and regulatory mechanisms of Piezo1 and its impact on innate and adaptive immunity. This may offer new insights into diagnostics and therapeutics for the prevention and treatment of diseases and surgical infections.
人体免疫系统能够防御、监测和自我稳定各种免疫细胞。这些细胞的分化、增殖和发育受生化信号的调节。此外，研究发现生物物理信号（如机械力）也会影响免疫细胞的功能，从而引入了免疫学研究的一个新领域。机械敏感离子通道 Piezo1 于 2021 年获得诺贝尔生理学或医学奖。该通道存在于许多细胞的表面，当受到机械力刺激时，它控制细胞内的钙离子 (Ca)，导致下游信号发生变化，从而调节细胞功能。Piezo1 也在各种先天和适应性免疫细胞中表达，对免疫功能起着重要作用。在这篇综述中，我们将探讨 Piezo1 的生理功能和调节机制及其对先天和适应性免疫的影响。这可能为疾病和手术感染的预防和治疗的诊断和治疗提供新的思路。
