Department of Cardiothoracic Surgery, St. Bartholomew's Hospital, London, UK; PhD School Angio-Cardio-Thoracic Pathophysiology and Imaging, Sapienza University, Rome, Italy.
Department of Cardiothoracic Surgery, St. Bartholomew's Hospital, London, UK.
Ann Vasc Surg. 2024 Nov;108:346-354. doi: 10.1016/j.avsg.2024.06.009. Epub 2024 Jul 14.
To investigate impact of frozen elephant trunk (FET) on long-term distal aortic remodeling in acute A aortic dissection (AAD) according to the latest recommended standards from the Society for Vascular Surgery (SVS)/Society of Thoracic Surgeons (STS).
Clinical data and imaging of patients who underwent FET to treat acute AAD over the last 8 years were retrospectively reviewed. Patients were included if a pre and postoperative computed angio tomographies at least 30 days from surgery was available for comparison. Contrasted postprocessed imaging were analyzed with Aquarius iNtuition (TeraRecon Inc., Foster City, CA, USA) to analyze long-term positive aortic remodeling, false lumen thrombosis, and aortic expansion according to the SVS or STS recommendations. Secondary endpoints were the rate of in-hospital and long-term mortality, spinal cord ischemia (SCI), and aortic-related reinterventions.
Out of 75 patients who underwent FET for type A AAD, n = 41 (54.6%) were included. Significant positive aortic remodeling was reported in Ishimaru zone 1-4 but not in visceral or infrarenal aorta (P < 0.001), and the overall rate of false lumen thrombosis was 95.1% (n = 39). Aortic expansion rates were as follows: 4.9% in zones 1-4, 8.3% in zones 5-6, and 15% in zone 7. The rates of in-hospital mortality and long-term mortality were 7.3% (n = 3) and 9.7% (n = 4), respectively. At a median follow-up of 11 months (range 1-141, reintervention rate was 17.1%.
We report positive aortic remodeling of the distal thoracic aorta in patients who underwent FET for acute AAD according to the SVS or STS reporting standards. The positive effect on the distal aorta is limited to the thoracic segments but not in the visceral aorta.
根据血管外科学会(SVS)/胸外科学会(STS)的最新推荐标准,研究冷冻象鼻(FET)对急性 A 型主动脉夹层(AAD)的长期远端主动脉重塑的影响。
回顾性分析过去 8 年接受 FET 治疗急性 AAD 的患者的临床数据和影像学资料。如果术后至少 30 天有术前和术后计算机血管断层扫描(CTA)可供比较,则将患者纳入研究。使用 Aquarius iNtuition(TeraRecon Inc.,加利福尼亚州福斯特市)对对比后的后处理图像进行分析,根据 SVS 或 STS 的建议分析长期阳性主动脉重塑、假腔血栓形成和主动脉扩张。次要终点是院内和长期死亡率、脊髓缺血(SCI)和主动脉相关再介入的发生率。
在 75 例接受 FET 治疗 A 型 AAD 的患者中,n=41(54.6%)被纳入研究。Ishimaru 1-4 区报告有显著的阳性主动脉重塑,但内脏或肾下主动脉无阳性重塑(P<0.001),假腔血栓形成的总体发生率为 95.1%(n=39)。主动脉扩张率如下:1-4 区 4.9%,5-6 区 8.3%,7 区 15%。院内死亡率和长期死亡率分别为 7.3%(n=3)和 9.7%(n=4)。中位随访时间为 11 个月(范围 1-141),再介入率为 17.1%。
根据 SVS 或 STS 的报告标准,我们报告了接受 FET 治疗的急性 AAD 患者的远端胸主动脉阳性重塑。对远端主动脉的积极影响仅限于胸段,而不包括内脏主动脉。